M
Michael Sundström
Researcher at Karolinska University Hospital
Publications - 86
Citations - 3530
Michael Sundström is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Crystal structure & Drug discovery. The author has an hindex of 18, co-authored 85 publications receiving 3144 citations. Previous affiliations of Michael Sundström include Karolinska Institutet & University of Copenhagen.
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Journal ArticleDOI
The promise and peril of chemical probes.
Cheryl H. Arrowsmith,James E. Audia,Christopher M. Austin,Jonathan B. Baell,Jonathan Bennett,Julian Blagg,C. Bountra,Paul Brennan,Peter Brown,Mark E. Bunnage,Carolyn Buser-Doepner,Robert M. Campbell,Adrian Carter,Philip Cohen,Robert A. Copeland,Ben Cravatt,Jayme L. Dahlin,Dashyant Dhanak,Aled M. Edwards,Mathias Frederiksen,Stephen V. Frye,Nathanael S. Gray,Charles E. Grimshaw,David Hepworth,Trevor Howe,Kilian Huber,Jian Jin,Stefan Knapp,Joanne Kotz,Ryan G. Kruger,Derek B. Lowe,Mary M. Mader,Brian D. Marsden,Anke Mueller-Fahrnow,Susanne Müller,Ronan C. O'Hagan,John P. Overington,Dafydd R. Owen,Saul H Rosenberg,Bryan L. Roth,Ruth A. Ross,Matthieu Schapira,Stuart L. Schreiber,Brian K. Shoichet,Michael Sundström,Giulio Superti-Furga,Jack Taunton,Leticia Toledo-Sherman,Chris Walpole,Michael A. Walters,Timothy M. Willson,Paul Workman,Robert N. Young,William J. Zuercher +53 more
TL;DR: A community-driven wiki resource to improve quality and convey current best practice on chemical probes, and to help address shortcomings of poor quality or that are used incorrectly generate misleading results.
Journal ArticleDOI
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.
Masoud Vedadi,Frank H. Niesen,Abdellah Allali-Hassani,Oleg Fedorov,P.J. Finerty,Gregory A. Wasney,Ron Yeung,Cheryl H. Arrowsmith,Linda J. Ball,Helena Berglund,Raymond Hui,Brian D. Marsden,Pär Nordlund,Michael Sundström,J. Weigelt,Aled M. Edwards +15 more
TL;DR: Two screening platforms are implemented, based on either fluorimetry or static light scattering, to measure the increase in protein thermal stability upon binding of a ligand without the need to monitor enzyme activity, and a small molecule was identified that stabilized the proteins and promoted structure determination.
Journal ArticleDOI
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases
Oleg Fedorov,Brian D. Marsden,Vanda Pogacic,P. Rellos,Susanne Müller,Alex N. Bullock,Juerg Schwaller,Michael Sundström,Stefan Knapp +8 more
TL;DR: This analysis evaluated the specificity of 156 validated kinase inhibitors, including inhibitors used in clinical trials, against 60 human Ser/Thr kinases using a thermal stability shift assay and revealed many unexpected cross-reactivities for inhibitors thought to be specific for certain targets.
Journal ArticleDOI
Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
X. Yang,Wen Hwa Lee,Frank Sobott,E. Papagrigoriou,Carol V. Robinson,Jorg Gunter Grossmann,Michael Sundström,Declan A. Doyle,Jonathan M. Elkins +8 more
TL;DR: Structural detail for five 14-3-3 isoforms bound to ligands is provided, providing structural coverage for all isoforms of a human protein family, and shows that the 14- 3-3 proteins are adaptable structures in which internal flexibility is likely to facilitate recognition and binding of their interaction partners.
Journal ArticleDOI
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
S.S. Ng,Kathryn L. Kavanagh,Michael A. McDonough,Danica Butler,Ewa S. Pilka,Benoît M. R. Liénard,James E. Bray,Pavel Savitsky,Opher Gileadi,Frank von Delft,Nathan R. Rose,John Offer,Johanna C. Scheinost,Tomasz Borowski,Michael Sundström,Christopher J. Schofield,Udo Oppermann +16 more
TL;DR: How human JMJD2A (jumonji domain containing 2A), which is selective towards tri- and dimethylated histone H3 lysyl residues 9 and 36, discriminates between methylation states and achieves sequence selectivity for H3K9 is revealed.