J
John Offer
Researcher at Francis Crick Institute
Publications - 44
Citations - 2256
John Offer is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Peptide bond & Native chemical ligation. The author has an hindex of 19, co-authored 44 publications receiving 2024 citations. Previous affiliations of John Offer include Scripps Research Institute & National Institute for Medical Research.
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Advances in Fmoc solid‐phase peptide synthesis
TL;DR: The number of synthetic peptides entering clinical trials has grown continuously over the last decade, and recent advances in the Fmoc SPPS technology are a response to the growing demand from medicinal chemistry and pharmacology.
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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.
S.S. Ng,Kathryn L. Kavanagh,Michael A. McDonough,Danica Butler,Ewa S. Pilka,Benoît M. R. Liénard,James E. Bray,Pavel Savitsky,Opher Gileadi,Frank von Delft,Nathan R. Rose,John Offer,Johanna C. Scheinost,Tomasz Borowski,Michael Sundström,Christopher J. Schofield,Udo Oppermann +16 more
TL;DR: How human JMJD2A (jumonji domain containing 2A), which is selective towards tri- and dimethylated histone H3 lysyl residues 9 and 36, discriminates between methylation states and achieves sequence selectivity for H3K9 is revealed.
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Exploiting the defensive sugars of HIV-1 for drug and vaccine design
TL;DR: Recent findings suggest that protective structural carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.
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Extending synthetic access to proteins with a removable acyl transfer auxiliary
TL;DR: This methodology enables unprotected peptides to be coupled at noncysteine ligation sites expanding the scope of protein synthesis and semisynthesis.
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Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation
Serena Sanulli,Serena Sanulli,Serena Sanulli,Neil Justin,Aurélie Teissandier,Aurélie Teissandier,Aurélie Teissandier,Katia Ancelin,Katia Ancelin,Katia Ancelin,Manuela Portoso,Manuela Portoso,Manuela Portoso,Matthieu Caron,Matthieu Caron,Matthieu Caron,Audrey Michaud,Audrey Michaud,Audrey Michaud,Bérangère Lombard,Simão Teixeira da Rocha,Simão Teixeira da Rocha,Simão Teixeira da Rocha,John Offer,Damarys Loew,Nicolas Servant,Nicolas Servant,Nicolas Servant,Michel Wassef,Michel Wassef,Michel Wassef,Fabienne Burlina,Steve J. Gamblin,Edith Heard,Edith Heard,Edith Heard,Raphaël Margueron,Raphaël Margueron,Raphaël Margueron +38 more
TL;DR: It is shown that Jarid2 methylation is important to promote PRC2 activity at a locus devoid of H3K27me3 and for the correct deposition of this mark during cell differentiation, uncovering a regulation loop where Jarid 2 methylation fine-tunes PRC 2 activity depending on the chromatin context.