M
Michael T. Liu
Researcher at Harvard University
Publications - 35
Citations - 2686
Michael T. Liu is an academic researcher from Harvard University. The author has contributed to research in topics: Chemokine & Meibomian gland. The author has an hindex of 18, co-authored 35 publications receiving 2532 citations. Previous affiliations of Michael T. Liu include University of California, Irvine.
Papers
More filters
Journal ArticleDOI
IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking
Jennifer H. Dufour,Michelle Dziejman,Michael T. Liu,Josephine H. Leung,Thomas E. Lane,Andrew D. Luster +5 more
TL;DR: A role for IP-10 is suggested in both effector T cell generation and trafficking in vivo, as seen in many Th1-type inflammatory diseases.
Journal ArticleDOI
Cutting edge: The T cell chemoattractant IFN-inducible protein 10 is essential in host defense against viral-induced neurologic disease
Michael T. Liu,Benjamin P. Chen,Patricia Oertel,Michael J. Buchmeier,David A. Armstrong,Thomas A. Hamilton,Thomas E. Lane +6 more
TL;DR: Data indicate that IP-10 functions as a sentinel molecule in host defense and is essential in the development of a protective Th1 response against viral infection of the CNS.
Journal ArticleDOI
A central role for CD4(+) T cells and RANTES in virus-induced central nervous system inflammation and demyelination.
Thomas E. Lane,Michael T. Liu,Benjamin P. Chen,Valérie C. Asensio,Roger M. Samawi,Alyssa D. Paoletti,Iain L. Campbell,S L Kunkel,Howard S. Fox,Michael J. Buchmeier +9 more
TL;DR: Data indicate that CD4+ T cells have a pivotal role in accelerating CNS inflammation and demyelination within infected mice, possibly by regulating RANTES expression, which in turn coordinates the trafficking of macrophages into the CNS, leading to myelin destruction.
Journal ArticleDOI
Neutralization of the Chemokine CXCL10 Reduces Inflammatory Cell Invasion and Demyelination and Improves Neurological Function in a Viral Model of Multiple Sclerosis
TL;DR: A novel therapeutic strategy using Ab-mediated neutralization of a key chemokine as a possible treatment for chronic human inflammatory demyelinating diseases such as MS is document.
Journal ArticleDOI
Reducing inflammation decreases secondary degeneration and functional deficit after spinal cord injury.
TL;DR: It is concluded that CXCL10 plays a critical role in recruitment of T lymphocytes to sites of spinal cord injury, and that a reduction of T-lymphocyte recruitment significantly enhances tissue preservation and functional outcome.