Michael T. Treadway

TL;DR: Between-group differences in prefrontal cortical thickness were most pronounced in older participants, suggesting that meditation might offset age-related cortical thinning, and data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice.

TL;DR: It is suggested that a refined definition of anhedonia that distinguishes between deficits in pleasure and motivation is essential for the purposes of identifying its neurobiological substrates and introduced the term "decisionalAnhedonia" to address the influence of anhydonia on reward decision-making.

TL;DR: It is suggested that anhedonia is specifically associated with decreased motivation for rewards, and initial validation for the EEfRT as a laboratory-based behavioral measure of reward motivation and effort-based decision-making in humans is provided.

TL;DR: It is found that higher levels of trait impulsivity were predicted by diminished midbrain D2/D3 autoreceptor binding and greater amphetamine-induced DA release in the striatum, which was in turn associated with stimulant craving.

TL;DR: New evidence of reward processing abnormalities in MDD, bipolar disorder and schizophrenia has led to a greater understanding of the neural processes associated with symptomatology common across these conditions, andsecting various subcomponents of rewardprocessing that map onto partially different neurobiological pathways and investigating their dysregulation in different psychiatric disorders holds promise for developing more targeted, and hopefully efficacious treatment and intervention strategies.