M
Michael Tigges
Publications - 3
Citations - 1957
Michael Tigges is an academic researcher. The author has contributed to research in topics: Transduction (genetics) & ELISPOT. The author has an hindex of 3, co-authored 3 publications receiving 1774 citations.
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Journal ArticleDOI
Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Catherine S. Manno,Glenn F. Pierce,Valder R. Arruda,Bertil Glader,Margaret V. Ragni,Rasko Jj,Margareth C. Ozelo,Keith Hoots,Blatt P,Barbara A. Konkle,Michael D. Dake,Robin D. Kaye,Mahmood K. Razavi,A Zajko,James L. Zehnder,Pradip Rustagi,Hiroyuki Nakai,A Chew,Debra G.B. Leonard,Debra G.B. Leonard,J F Wright,Ruth Lessard,Jurg M. Sommer,Michael Tigges,Denise E. Sabatino,A Luk,Haiyan Jiang,Federico Mingozzi,Linda B. Couto,Hildegund C.J. Ertl,Katherine A. High,Katherine A. High,Mark A. Kay +32 more
TL;DR: In this article, a single portal vein infusion of a recombinant adeno-associated viral vector (rAAV) expressing canine Factor IX (F.IX) resulted in long-term expression of therapeutic levels of F.IX in dogs with severe hemophilia B.
Journal ArticleDOI
Human Immune Responses to AAV-2 Capsid May Limit Duration of Expression in Liver-Directed Gene Transfer in Humans with Hemophilia B.
Katherine A. High,Katherine A. High,Katherine A. High,Michael Tigges,Catherine S. Manno,Catherine S. Manno,Denise E. Sabatino,Valder R. Arruda,Valder R. Arruda,Roland W. Herzog,Roland W. Herzog,Pradip Rustagi,John E.J. Rasko,Jurg M. Sommer,Kristen Jaworski,Margaret V. Ragni,Bertil Glader,Ruth Lessard,Alvin Luk,Linda B. Couto,Haiyan Jiang,Glenn F. Pierce,Mark A. Kay +22 more
TL;DR: Data from a Phase I dose escalation study of AAV-FIX in humans with severe hemophilia B are consistent with a model in which a T cell response to AAV capsid epitopes results in elimination of the transduced cells.
Journal ArticleDOI
Correction: Corrigendum: Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response
Catherine S. Manno,Valder R. Arruda,Glenn F. Pierce,Bertil Glader,Margaret V. Ragni,John E.J. Rasko,Margareth C. Ozelo,Keith Hoots,Blatt P,Barbara A. Konkle,Mike Dake,Robin D. Kaye,Mahmood K. Razavi,A Zajko,James L. Zehnder,Hiroyuki Nakai,A Chew,Debra G.B. Leonard,Debra G.B. Leonard,J F Wright,J F Wright,Ruth Lessard,Jurg M. Sommer,Michael Tigges,Denise E. Sabatino,A Luk,Haiyan Jiang,Federico Mingozzi,Linda B. Couto,Hildegund C. J. Ertl,Hildegund C. J. Ertl,Katherine A. High,Katherine A. High,Mark A. Kay +33 more
TL;DR: In the version of this article originally published, Pradip Rustagi was inadvertently omitted from the author list and John Rasko should be listed as John E. J. Raskso.