M
Michael Tuen
Researcher at New York University
Publications - 34
Citations - 845
Michael Tuen is an academic researcher from New York University. The author has contributed to research in topics: Antibody & Epitope. The author has an hindex of 17, co-authored 33 publications receiving 763 citations. Previous affiliations of Michael Tuen include Veterans Health Administration.
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Journal ArticleDOI
Preferential HIV Infection of CCR6+ Th17 Cells Is Associated with Higher Levels of Virus Receptor Expression and Lack of CCR5 Ligands
Yelina Alvarez,Michael Tuen,Guomiao Shen,Fatima Nawaz,Fatima Nawaz,James Arthos,Martin J. Wolff,Michael A. Poles,Catarina E. Hioe +8 more
TL;DR: Results indicate that features unique to Th17 cells, including higher expression of HIV receptors and lack of autocrine CCR5 ligands, are associated with enhanced permissiveness of these cells to HIV.
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LFA-1 Expression on Target Cells Promotes Human Immunodeficiency Virus Type 1 Infection and Transmission
Catarina E. Hioe,Peter Chien,Chafen Lu,Timothy A. Springer,Xiao-Hong Wang,Juan C. Bandres,Michael Tuen +6 more
TL;DR: The presence of wild-type LFA-1 enhanced the initial processes of HIV infection, as well as the subsequent replication and transmission from cell to cell, even though this mutant could help HIV enter cells and establish the initial infection.
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Human Immunodeficiency Virus Type 1 Envelope gp120 Induces a Stop Signal and Virological Synapse Formation in Noninfected CD4+ T Cells
Gaia Vasiliver-Shamis,Michael Tuen,Teresa W. Wu,Toby Starr,Thomas O. Cameron,Russell Thomson,Gurvinder Kaur,Gurvinder Kaur,Jianping Liu,Maria Luisa Visciano,Hualin Li,Rajnish Kumar,Rais A Ansari,Dong P. Han,Michael W. Cho,Michael L. Dustin,Catarina E. Hioe +16 more
TL;DR: HIV-1 gp120-presenting surfaces induce a transient stop signal and supramolecular segregation in noninfected CD4+ T cells in order to efficiently transfer HIV-1 virions from cell to cell.
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The use of immune complex vaccines to enhance antibody responses against neutralizing epitopes on HIV-1 envelope gp120
Catarina E. Hioe,Maria Luisa Visciano,Rajnish Kumar,Jianping Liu,Ethan A. Mack,Rachel E. Simon,David N. Levy,Michael Tuen,Michael Tuen +8 more
TL;DR: Overall this study shows the potential use of gp120/Ab complexes to augment the immunogenicity of HIV-1 envelope gp120, but further improvements are needed to elicit virus-neutralizing Ab responses with higher potency and breadth.
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HIV-1 N-Glycan Composition Governs a Balance between Dendritic Cell-Mediated Viral Transmission and Antigen Presentation
Thijs van Montfort,Dirk Eggink,Maikel Boot,Michael Tuen,Catarina E. Hioe,Ben Berkhout,Rogier W. Sanders,Rogier W. Sanders +7 more
TL;DR: The results showed that the HIV-1 N-glycan composition plays a crucial role in the balance between DC-mediated Ag degradation and presentation and HIV-mediated virus transmission to target cells.