Michael V. Sofroniew

TL;DR: This article showed that uninjured basal forebrain cholinergic neurons did not die after excitotoxic ablation of their target neurons in young adult rats, indicating that they are either not dependent on neurotrophic factors for survival or can obtain trophic support from other sources after target neurons are lost.

TL;DR: Developmental analysis provides further evidence that there is a high degree of conservation in the topographic organization of the numerous diverse NPH‐IR cell groups in humans and other mammals, suggesting that the separation and organization of these groups may be of functional importance.

TL;DR: Findings indicate that NGF can induce the sprouting of uninjured adult rat septal cholinergic fibres in vivo and suggest that reactive astrocytes are not inhibitory toCholinergic axonal outgrowth, and might serve as a substrate for growing axons in the presence of NGF.

TL;DR: In this article , the authors developed CRISPR interference screening in human induced pluripotent stem cell-derived astrocytes coupled with single-cell transcriptomics to systematically interrogate cytokine-induced inflammatory inflammatory Astrocyte reactivity and found that autocrine-paracrine IL-6 and interferon signaling downstream of canonical NF-κB activation drove two distinct inflammatory reactive signatures, one promoted by STAT3 and the other inhibited by STAT 3.

TL;DR: Detailed surgical methods to express GECIs in astrocytes in vivo, and confocal imaging approaches to record [Ca(2+)]i signals in striatal astroCytes in situ, are described.