M
Martin Kampmann
Researcher at University of California, San Francisco
Publications - 127
Citations - 10278
Martin Kampmann is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: CRISPR & Biology. The author has an hindex of 35, co-authored 95 publications receiving 7294 citations. Previous affiliations of Martin Kampmann include Laboratory of Molecular Biology & Howard Hughes Medical Institute.
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Journal ArticleDOI
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Luke A. Gilbert,Max A. Horlbeck,Britt Adamson,Jacqueline E. Villalta,Yuwen Chen,Evan H. Whitehead,Carla P. Guimaraes,Barbara Panning,Hidde L. Ploegh,Michael C. Bassik,Lei S. Qi,Martin Kampmann,Jonathan S. Weissman +12 more
TL;DR: This work identifies rules for specific targeting of transcriptional repressors (CRISPRi), typically achieving 90%-99% knockdown with minimal off-target effects, and activators to endogenous genes via endonuclease-deficient Cas9, which enable modulation of gene expression over a ∼1,000-fold range.
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
Luke A. Gilbert,Max A. Horlbeck,Britt Adamson,Jacqueline E. Villalta,Yuwen Chen,Evan H. Whitehead,Carla P. Guimaraes,Barbara Panning,Michael C. Bassik,Lei S. Qi,Martin Kampmann,Jonathan S. Weissman,Hidde L. Ploegh +12 more
TL;DR: In this article, the authors identify rules for specific targeting of transcriptional repressors (CRISPRi), typically achieving 90%-99% knockdown with minimal off-target effects, and activators (CRisPRa) to endogenous genes via endonuclease-deficient Cas9.
Journal ArticleDOI
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
Max A. Horlbeck,Luke A. Gilbert,Jacqueline E. Villalta,Brittany Adamson,Ryan A. Pak,Ryan A. Pak,Yuwen Chen,Alexander P. Fields,Chong Yon Park,Chong Yon Park,Jacob E. Corn,Martin Kampmann,Jonathan S. Weissman +12 more
TL;DR: A comprehensive algorithm that incorporates chromatin, position, and sequence features to accurately predict highly effective single guide RNAs (sgRNAs) for targeting nuclease-dead Cas9-mediated transcriptional repression (CRISPRi) and activation ( CRISPRa) is built.
Journal ArticleDOI
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
Michael C. Bassik,Martin Kampmann,Robert Jan Lebbink,Shuyi Wang,Marco Y. Hein,Ina Poser,Jimena Weibezahn,Max A. Horlbeck,Siyuan Chen,Matthias Mann,Anthony A. Hyman,Emily M LeProust,Michael T. McManus,Jonathan S. Weissman +13 more
TL;DR: The ability to rapidly generate mammalian GI maps provides a potentially transformative tool for defining gene function and designing combination therapies based on synergistic pairs.
Journal ArticleDOI
Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis
Daniel Anderson,Ronan Le Moigne,Stevan Djakovic,Brajesh Kumar,Julie Rice,Steve Wong,Jinhai Wang,Bing Yao,Eduardo Valle,Szerenke Kiss von Soly,Antonett Madriaga,Ferdie Soriano,Mary-Kamala Menon,Zhi Yong Wu,Martin Kampmann,Yuwen Chen,Jonathan S. Weissman,Blake T. Aftab,F. Michael Yakes,Laura K. Shawver,Han-Jie Zhou,David J. Wustrow,Mark Rolfe +22 more
TL;DR: CB-5083 causes modulation of key p97-related pathways, induces apoptosis, and has antitumor activity in a broad range of both hematological and solid tumor models, providing a potential strategy for patient selection.