M
Michael W. Owens
Researcher at Louisiana State University
Publications - 32
Citations - 1074
Michael W. Owens is an academic researcher from Louisiana State University. The author has contributed to research in topics: Nitric oxide & Mesothelial Cell. The author has an hindex of 17, co-authored 30 publications receiving 1042 citations. Previous affiliations of Michael W. Owens include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Statins Reduce the Risk of Lung Cancer in Humans: A Large Case-Control Study of US Veterans
TL;DR: Statins appear to be protective against the development of lung cancer, and further studies need to be done to define the clinical utility of statins as chemo protective agents.
Journal ArticleDOI
Nitric oxide synthase in circulating vs. extravasated polymorphonuclear leukocytes
Allen M. Miles,Michael W. Owens,Shawn A. Milligan,Glenda G. Johnson,Jeremy Z. Fields,Jeremy Z. Fields,Todd S. Ing,Venkata Kottapalli,Ali Keshavarzian,Ali Keshavarzian,Matthew B. Grisham +10 more
TL;DR: It is demonstrated that inflammation‐induced extravasation of rat PMNs upregulates the transcription and translation of iNOS in a time‐dependent fashion and that 20–30% of the total inducible NOS is Ca2+‐dependent.
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Elevation of nitrotyrosine and nitrate concentrations in cystic fibrosis sputum.
Kimberly L. Jones,Alaa H. Hegab,Bettina C. Hillman,Keith Simpson,Patricia A. Jinkins,Matthew B. Grisham,Michael W. Owens,Etsuro Sato,Richard A. Robbins +8 more
TL;DR: This work hypothesized that superoxide released from neutrophils in the lower respiratory tract of cystic fibrosis results in increased nitrate and nitrotyrosine levels in sputum, and collected exhaled NO from stable adult CF subjects and from nonsmoking normal controls.
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Superoxide released from neutrophils causes a reduction in nitric oxide gas
Kimberly L. Jones,Ty W. Bryan,Patricia A. Jinkins,Keith Simpson,Matthew B. Grisham,Michael W. Owens,Shawn A. Milligan,Boaz A. Markewitz,Richard A. Robbins +8 more
TL;DR: It is demonstrated that activated polymorphonuclear neutrophils released from PMNs can decrease NO by conversion to nitrate and suggest a potential mechanism for modulation of NO levels in vivo.
Journal ArticleDOI
Effects of reactive metabolites of oxygen and nitrogen on gelatinase A activity
TL;DR: It is postulate that the relative fluxes of nitric oxide and superoxide at sites of inflammation may modulate metalloproteinase activity and thus affect matrix protein metabolism.