Michal Levy-Sakin

TL;DR: This study describes an approach to performing de novo genome assembly and experimental phasing by integrating the data from Illumina short-read sequencing, 10X Genomics linked- read sequencing, and BioNano Genomics genome mapping to yield a high-quality, phased, de noVO assembled human genome.

TL;DR: 1,4-naphthoquinon-2-yl-L-tryptophan (NQTrp), a rationally designed inhibitor of the Alzheimer's disease-associated β-amyloid that combines the recognition capacities of both quinone and tryptophan moieties and completely inhibited Aβ oligomerization and fibrillization, as well as the cytotoxic effect of A β oligomers towards cultured neuronal cell line.

TL;DR: Analyzing optical genome maps of 154 individuals from the 26 populations sequenced in the 1000 Genomes Project, it is found that phylogenetic population patterns of large SVs are similar to those of single nucleotide variations in 86% of the human genome, while ~2% ofThe genome has high structural complexity.

TL;DR: This work explores the assembly of peptide nucleic acids (PNAs), which are short DNA mimics that have an amide backbone, and finds them to exhibit optical properties including voltage-dependent electroluminescence and wide-range excitation-dependent fluorescence in the visible region.

TL;DR: The advances of these methods in light of recent developments in nano-fabrication and super-resolution optical imaging are discussed and the latest achievements of optical mapping in the context of genomic analysis are reviewed.