Han Cao

TL;DR: A suite of long-read, short- read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms are applied to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner.

TL;DR: It is shown that genomic-length DNA molecules imaged in nanochannels have an extension along the channel that scales linearly with the contour length of the polymer, in agreement with the scaling arguments developed by de Gennes for self-avoiding confined polymers.

TL;DR: The sequencing and assembly of the 32-gigabase-pair axolotl genome is reported using an approach that combined long-read sequencing, optical mapping and development of a new genome assembler (MARVEL).

TL;DR: In this article, the authors made uniform arrays of nanometer scale structures using nanoimprint lithography over large areas (100 mm wafers) and sealed the nanofluidic channels by techniques based on nonuniform deposition.

TL;DR: This paper gives a few examples from the literature and from the own research in the field of miniaturized chip-based devices for DNA analysis, including dielectrophoresis for purification of DNA, artificial gel structures for rapid DNA separation, and nanofluidic channels for direct visualization of single DNA molecules.