M
Michel Grandbois
Researcher at Université de Sherbrooke
Publications - 78
Citations - 3913
Michel Grandbois is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Surface plasmon resonance & Cytoskeleton. The author has an hindex of 29, co-authored 75 publications receiving 3574 citations. Previous affiliations of Michel Grandbois include University of Missouri & Université de Montréal.
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Journal ArticleDOI
How Strong Is a Covalent Bond
Michel Grandbois,Martin K. Beyer,Matthias Rief,Matthias Rief,Hauke Clausen-Schaumann,Hermann E. Gaub +5 more
TL;DR: The rupture force of single covalent bonds under an external load was measured with an atomic force microscope (AFM) and calculations that were based on density functional theory corroborate the measured values.
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Multiple membrane tethers probed by atomic force microscopy.
Mingzhai Sun,John S. Graham,John S. Graham,Balazs Hegedus,Francoise Marga,Ying Zhang,Gabor Forgacs,Michel Grandbois +7 more
TL;DR: The results demonstrate the ability of the plasma membrane to locally produce multiple interdependent tethers-a process that could play an important role in the mechanical association of cells with their environment.
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Affinity Imaging of Red Blood Cells Using an Atomic Force Microscope
TL;DR: Results show that the adhesion, mediated by only a few receptor-ligand pairs, produces sufficient contrast for the affinity image formation.
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Atomic Force Microscope Imaging of Phospholipid Bilayer Degradation by Phospholipase A2
TL;DR: These experiments suggest that it is possible to observe single enzymes at work in small channels, which are created by the hydrolysis of membrane phospholipids, and supports the single-enzyme hypothesis.
Journal ArticleDOI
G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm.
Fernand Gobeil,Fernand Gobeil,Audrey Fortier,Audrey Fortier,Tang ZhuT. Zhu,Tang ZhuT. Zhu,Michela Bossolasco,Michela Bossolasco,Martin Leduc,Martin Leduc,Michel Grandbois,Michel Grandbois,Nikolaus Heveker,Nikolaus Heveker,Ghassan Bkaily,Ghassan Bkaily,Sylvain Chemtob,Sylvain Chemtob,David BarbazD. Barbaz,David BarbazD. Barbaz +19 more
TL;DR: There is compelling evidence for a novel intracrine mode of genomic regulation by GPCRs that implies either the endocytosis and nuclear translocation of peripheral-liganded G PCR and (or) the activation of nuclearly located GPCR by endogenously produced, nonsecreted ligands.