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Michel Lagarde

Researcher at French Institute of Health and Medical Research

Publications -  144
Citations -  3646

Michel Lagarde is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Arachidonic acid & Docosahexaenoic acid. The author has an hindex of 33, co-authored 144 publications receiving 3519 citations. Previous affiliations of Michel Lagarde include University of Lyon & Institut national des sciences appliquées.

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Journal ArticleDOI

Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain

Frank Thies, +4 more
- 01 Nov 1994 - 
TL;DR: Only the brain preferentially incorporated unsaturated (but not saturated) lysoPC, with the uptake increasing with the degree of unsaturation of the fatty acid moiety.
Journal ArticleDOI

The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress.

Nicolas J. Pillon, +14 more
- 06 Mar 2012 - 
TL;DR: 4-HNE can impair insulin action in muscle cells through oxidative stress and oxidative damage to proteins, eventually leading to insulin resistance, which could represent a novel strategy to combat insulin resistance and other oxidative stress-associated pathologies.

Original Contribution ADVANCED GLYCATION END-PRODUCTS INDUCE APOPTOSIS OF BOVINE RETINAL PERICYTES IN CULTURE: INVOLVEMENT OF DIACYLGLYCEROL/CERAMIDE PRODUCTION AND OXIDATIVE STRESS INDUCTION

Ulriche Denis, +5 more
TL;DR: In this paper, the authors tested the hypothesis that AGE might be involved in the disappearance of retinal pericytes by apoptosis and further investigated the signaling pathway leading to cell death.
Journal ArticleDOI

Unsaturated Fatty Acids Esterified in 2-Acyl-1-Lysophosphatidylcholine Bound to Albumin Are More Efficiently Taken up by the Young Rat Brain than the Unesterified Form

Frank Thies, +4 more
- 01 Sep 1992 - 
TL;DR: Results suggest that 2‐acyl‐lysophosphatidylcholine bound to albumin could be an efficient delivery form of unsaturated fatty acids to the developing rat brain and that the fatty acid delivery form could modulate their fate in the tissue.
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Biosynthesis and inactivation of n-arachidonoylethanolamine (anandamide) and n-docosahexaenoylethanolamine in bovine retina

Tiziana Bisogno, +4 more
- 15 Oct 1999 - 
TL;DR: Data indicate that AEA and its congeners may play a physiological role in the mammalian eye and it is found that isolated particulate fractions from bovine retina could release A EA and DHEA in a time-dependent fashion.