M
Michel Pfeffer
Researcher at University of Strasbourg
Publications - 38
Citations - 988
Michel Pfeffer is an academic researcher from University of Strasbourg. The author has contributed to research in topics: Ruthenium & Ligand. The author has an hindex of 17, co-authored 38 publications receiving 886 citations. Previous affiliations of Michel Pfeffer include Centre national de la recherche scientifique & University of Groningen.
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Journal ArticleDOI
Dynamic Kinetic Resolution of Racemic β-Haloalcohols : Direct Access to Enantioenriched Epoxides
Robert M. Haak,Florian Berthiol,Thomas Jerphagnon,Arnaud J. A. Gayet,Chiara Tarabiono,Christiaan P. Postema,Vincent Ritleng,Michel Pfeffer,Dick B. Janssen,Adriaan J. Minnaard,Ben L. Feringa,Johannes G. de Vries +11 more
TL;DR: The direct chemo-enzymatic DKR of racemic beta-haloalcohols is reported, yielding the corresponding optically active epoxides in a single step.
Journal ArticleDOI
Library of second-generation cycloruthenated compounds and evaluation of their biological properties as potential anticancer drugs: passing the nanomolar barrier.
Ludivine Fetzer,Bastien Boff,Moussa Ali,Meng Xiangjun,J.-P. Collin,Claude B. Sirlin,Christian Gaiddon,Michel Pfeffer +7 more
TL;DR: A library of 32 organoruthenium compounds has been synthesised and several of the newly synthesized compounds pass the symbolic barrier of the nanomolar range for their IC(50) indicating a critical improvement.
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Cyclometalated Complexes of Ruthenium, Rhodium and Iridium as Catalysts for Transfer Hydrogenation of Ketones and Imines
Nicolas Pannetier,Jean-Baptiste Sortais,Jean-Thomas Issenhuth,Laurent Barloy,Claude B. Sirlin,Alexandre Holuigue,Laurent Lefort,Lavinia Panella,Johannes G. de Vries,Michel Pfeffer +9 more
TL;DR: In this article, a library of organometallic compounds derived from primary and secondary amines cyclometalated by ruthenium(II), rhodium(III), and iridium(III) was tested in the asymmetric transfer hydrogenation of a number of ketones and imines.
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Induction of caspase 8 and reactive oxygen species by ruthenium-derived anticancer compounds with improved water solubility and cytotoxicity
Vania Vidimar,Xiangjun Meng,Xiangjun Meng,Marcelina Klajner,Marcelina Klajner,Cynthia Licona,Cynthia Licona,Ludivine Fetzer,Ludivine Fetzer,Sébastien Harlepp,Sébastien Harlepp,Pascal Hébraud,Pascal Hébraud,Marjorie Sidhoum,Marjorie Sidhoum,Claude B. Sirlin,Claude B. Sirlin,Jean-Philippe Loeffler,Jean-Philippe Loeffler,Georg Mellitzer,Georg Mellitzer,Gianni Sava,Michel Pfeffer,Michel Pfeffer,Christian Gaiddon,Christian Gaiddon +25 more
TL;DR: Water-soluble ruthenium(II)-derived compounds represent an interesting class of molecules that, depending on their structures, can target several pro-apoptotic signaling pathways leading to reactive oxygen species production and caspase 8 activation.
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Fast Racemisation of Chiral Amines and Alcohols by Using Cationic Half‐Sandwich Ruthena‐ and Iridacycle Catalysts
Thomas Jerphagnon,Arnaud J. A. Gayet,Florian Berthiol,Vincent Ritleng,Natasa Mrsic,Auke Meetsma,Michel Pfeffer,Adriaan J. Minnaard,Ben L. Feringa,Johannes G. de Vries +9 more
TL;DR: It is shown that cationic half-sandwich ruthena- and iridacycle complexes are highly active and efficient in the racemisation of chiral alcohols and amines.