Michele Aventaggiato

TL;DR: This study shows that hypoxia and autophagy by acting on common (HIF‐1α) or separate (MMPs, cytoskeleton) targets differently regulate cell invasion, MMPs activity, and survival.

TL;DR: Sirtuins role in the context of tumor progression and metastasis indicating glutamine metabolism as an example of how a concerted activation and/or inhibition of sirtUins in cancer cells can control autophagy and mitophagy by impinging on the metabolism of this fundamental amino acid.

TL;DR: It is concluded that SIRT1 silenced neurons appear more committed to differentiation and more resistant to cell death through the activation of IGF‐1 survival pathway.

TL;DR: It is demonstrated that in HeLa cells the ERK‐1 kinase prevents TNF + CHX apoptosis by regulating the intrinsic mitochondrial pathway through different mechanisms.

TL;DR: The dual role that mitophagy plays in cancer and age-related pathologies, as a consequence of oxidative stress, is discussed, evidencing the triggering stimuli and mechanisms and suggesting the molecular targets for its therapeutic control.