M
Michele Bellesi
Researcher at University of Bristol
Publications - 66
Citations - 2838
Michele Bellesi is an academic researcher from University of Bristol. The author has contributed to research in topics: Sleep deprivation & Sleep restriction. The author has an hindex of 25, co-authored 59 publications receiving 2110 citations. Previous affiliations of Michele Bellesi include University of Wisconsin-Madison & Philips.
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Journal ArticleDOI
Ultrastructural evidence for synaptic scaling across the wake/sleep cycle.
Luisa de Vivo,Michele Bellesi,Michele Bellesi,William Marshall,Eric A. Bushong,Mark H. Ellisman,Giulio Tononi,Chiara Cirelli +7 more
TL;DR: The hypothesis that a core function of sleep is to renormalize overall synaptic strength increased by wake is supported, as measured in mouse motor and sensory cortices.
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Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
TL;DR: Astrocytic phagocytosis of synaptic elements is upregulated already after a few hours of sleep deprivation and shows a further significant increase after prolonged and severe sleep loss, suggesting that it may promote the housekeeping of heavily used and strong synapses in response to the increased neuronal activity of extended wake.
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Enhancement of sleep slow waves: underlying mechanisms and practical consequences.
Michele Bellesi,Brady A. Riedner,Gary Garcia-Molina,Gary Garcia-Molina,Chiara Cirelli,Giulio Tononi +5 more
TL;DR: The converging evidence showing that acoustic stimulation is safe and represents an ideal tool for slow wave sleep (SWS) enhancement is reviewed, highlighting the physiology of the K-complex, a peripheral evoked slow wave, and how intensity and frequency of the acoustic stimuli affect sleep enhancement.
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Effects of Sleep and Wake on Oligodendrocytes and Their Precursors
Michele Bellesi,Martha Pfister-Genskow,Stéphanie Maret,Sunduz Keles,Giulio Tononi,Chiara Cirelli +5 more
TL;DR: OPC proliferation doubles during sleep and positively correlates with time spent in REM sleep, whereas OPC differentiation is higher during wake, thus, OPC proliferation and differentiation are not perfectly matched at any given circadian time but preferentially occur duringsleep and wake, respectively.
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Reduced Natural Oscillatory Frequency of Frontal Thalamocortical Circuits in Schizophrenia
Fabio Ferrarelli,Simone Sarasso,Yelena Guller,Brady A. Riedner,Michael J. Peterson,Michele Bellesi,Marcello Massimini,Bradley R. Postle,Giulio Tononi +8 more
TL;DR: These findings suggest that patients with schizophrenia have an intrinsic slowing in the natural frequency of frontal cortical/thalamocortical circuits, that this slowing is not present in parietal areas, and that the prefrontal natural frequency can predict some of the symptoms as well as the cognitive dysfunctions of schizophrenia.