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Michele G. Best

Researcher at United States Department of Veterans Affairs

Publications -  7
Citations -  722

Michele G. Best is an academic researcher from United States Department of Veterans Affairs. The author has contributed to research in topics: Legionella pneumophila & Legionella. The author has an hindex of 6, co-authored 7 publications receiving 712 citations. Previous affiliations of Michele G. Best include University of Pittsburgh.

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LEGIONELLACEAE IN THE HOSPITAL WATER-SUPPLY: Epidemiological Link with Disease and Evaluation of a Method for Control of Nosocomial Legionnaires' Disease and Pittsburgh Pneumonia

TL;DR: An epidemiological link was found between contamination of a hospital water-supply by Legionella pneumophila and by Pittsburgh pneumonia agent (PPA) and subsequent cases of nosocomial legionnaires' disease and Pittsburgh pneumonia.
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Ecology of Legionella pneumophila within water distribution systems.

TL;DR: The reservoir for hospital-acquired Legionnaires disease has been shown to be the potable water distribution system, and the influence of the natural microbial population and sediment found in water systems as growth-promoting factors for Legionella pneumophila is investigated.
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Ubiquitousness of Legionella pneumophila in the water supply of a hospital with endemic Legionnaires' disease.

TL;DR: SINCE 1977 there have been numerous outbreaks of nosocomial Legionnaires' disease; however, in only one was a reservoir established for Legionella pneumophila, and L. Dondero and his colleagues have suggested that the organisms were spread from a contaminated cooling tower adjacent to a hospital with 39 cases of Legionnaires'.
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Legionella pneumophila contamination of a hospital humidifier. Demonstration of aerosol transmission and subsequent subclinical infection in exposed guinea pigs.

TL;DR: It is shown that mechanically created aerosols of Legionella-contaminated potable water might be the vehicle of transmission of Legionnaires' disease, especially in the hospital setting.
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Tatlockia micdadei (Pittsburgh pneumonia agent) growth kinetics may explain its infrequent isolation from water and the low prevalence of Pittsburgh pneumonia.

TL;DR: The difference in the ecology between the two organisms may explain the infrequent environmental recovery of PPA and, ultimately, the epidemiologic differences between Legionnaires disease and Pittsburgh pneumonia.