M
Michele M. Kim
Researcher at University of Pennsylvania
Publications - 78
Citations - 1284
Michele M. Kim is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Photodynamic therapy & Photosensitizer. The author has an hindex of 15, co-authored 68 publications receiving 759 citations.
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Journal ArticleDOI
Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System.
Eric S. Diffenderfer,Ioannis I. Verginadis,Michele M. Kim,Khayrullo Shoniyozov,Anastasia Velalopoulou,Denisa Goia,Mary E. Putt,Sarah Hagan,Stephen Avery,K. Teo,Wei Zou,Alexander Lin,Samuel Swisher-McClure,Cameron J. Koch,Ann R. Kennedy,Andy J. Minn,Amit Maity,Theresa M. Busch,Lei Dong,Costas Koumenis,James M Metz,Keith A. Cengel +21 more
TL;DR: Using a novel RT apparatus that delivers FLASH proton RT (PRT) using double scattered protons with computed tomography guidance, it is found that FLASH-PRT decreases acute cell loss and late fibrosis after whole-abdomen and focal intestinal RT, whereas tumor growth inhibition is preserved between the 2 modalities.
Journal ArticleDOI
Light Sources and Dosimetry Techniques for Photodynamic Therapy
Michele M. Kim,Arash Darafsheh +1 more
TL;DR: The basic physics of light sources are summarized, methods for determining the dose delivered to the patient are described, and the selection of light source and delivery device appropriate to the target tissue are described.
Journal ArticleDOI
On the in vivo photochemical rate parameters for PDT reactive oxygen species modeling.
TL;DR: Most photosensitizer photochemical parameters discussed in this review are of the type II (singlet oxygen) photooxidation category, although type I photoensitizers that involve other reactive oxygen species (ROS) will be discussed as well.
Journal ArticleDOI
FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response.
Anastasia Velalopoulou,Ilias V. Karagounis,Gwendolyn M. Cramer,Michele M. Kim,Giorgos Skoufos,Giorgos Skoufos,Denisa Goia,Sarah Hagan,Ioannis I. Verginadis,Khayrullo Shoniyozov,June Chiango,Michelle Cerullo,Kelley M. Varner,Lutian Yao,Ling Qin,Artemis G. Hatzigeorgiou,Artemis G. Hatzigeorgiou,Andy J. Minn,Mary E. Putt,Matthew R. Lanza,Charles-Antoine Assenmacher,Enrico Radaelli,Jennifer L. Huck,Eric S. Diffenderfer,Lei Dong,James M. Metz,Constantinos Koumenis,Keith A. Cengel,Amit Maity,Theresa M. Busch +29 more
TL;DR: In this paper, the authors studied the effects of FLASH-proton radiotherapy (F-PRT) on skin and mesenchymal tissues of muscle and bone in the C57BL/6 murine hind leg.
Journal ArticleDOI
In-vivo singlet oxygen threshold doses for PDT.
TL;DR: An in-vivo model to determine the singlet oxygen threshold dose, [1O2]rx,sh, for photodynamic therapy (PDT) was developed in this paper.