Manlio Vinciguerra

TL;DR: It is shown that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes and decreased risk factors/biomarkers for aging, diabetes, cardiovascular disease, and cancer without major adverse effects, providing support for the use of FMDs to promote healthspan.

TL;DR: There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan.

TL;DR: In this paper, the authors identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies, including aneurysm formation.

TL;DR: The heart appears to be a target of systemic, and possibly locally generated, fibroblast growth factor 21, which exerts a protective action against cardiac hypertrophy.

TL;DR: Unsaturated fatty acids inhibit PTEN expression in hepatocytes by up‐regulating micro RNA‐21 synthesis via an mTOR/NF‐κB–dependent mechanism, and Aberrant up‐regulation of microRNA‐21 expression by excessive circulating levels of fatty acids exemplify a novel regulatory mechanism by which fatty acids affectPTEN expression and trigger liver disorders.