M
Michelle C. Y. Chang
Researcher at University of California, Berkeley
Publications - 65
Citations - 8691
Michelle C. Y. Chang is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Chemistry & Active site. The author has an hindex of 33, co-authored 58 publications receiving 7716 citations. Previous affiliations of Michelle C. Y. Chang include Massachusetts Institute of Technology & California Institute for Quantitative Biosciences.
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Journal ArticleDOI
Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Dae-Kyun Ro,Eric M. Paradise,Mario Ouellet,Karl Fisher,Karyn L. Newman,John M. Ndungu,Ho Kimberly,Eachus Rachel,Timothy S. Ham,James Kirby,Michelle C. Y. Chang,Sydnor T. Withers,Yoichiro Shiba,Richmond Sarpong,Jay D. Keasling +14 more
TL;DR: The engineering of Saccharomyces cerevisiae to produce high titres (up to 100 mg l-1) of artemisinic acid using an engineered mevalonate pathway, amorphadiene synthase, and a novel cytochrome P450 monooxygenase from A. annua that performs a three-step oxidation of amorpha-4,11-diene to art Artemisinic acid.
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Radical Initiation in the Class I Ribonucleotide Reductase: Long-Range Proton-Coupled Electron Transfer?
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A selective, cell-permeable optical probe for hydrogen peroxide in living cells.
TL;DR: Peroxyfluor-1 utilizes a boronate deprotection mechanism to provide unprecedented selectivity and optical dynamic range for detecting H2O2 in aqueous solution over similar reactive oxygen species including superoxide, nitric oxide, tert-butyl hydroperoxide, and hydroxyl radical.
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Production of isoprenoid pharmaceuticals by engineered microbes
TL;DR: In this article, the authors discuss ongoing research aimed toward the production of terpenoid natural products in genetically engineered Escherichia coli and Saccharomyces cerevisiae.
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Exploring bacterial lignin degradation.
TL;DR: Recent advances in studying bacterial lignin degradation as an approach to exploring greater diversity in the environment are discussed.