M
Michelle Christian
Researcher at University of Minnesota
Publications - 13
Citations - 5821
Michelle Christian is an academic researcher from University of Minnesota. The author has contributed to research in topics: Transcription activator-like effector nuclease & TAL effector. The author has an hindex of 9, co-authored 12 publications receiving 5364 citations. Previous affiliations of Michelle Christian include University of Electronic Science and Technology of China & Iowa State University.
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Journal ArticleDOI
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting
Tomas Cermak,Erin L. Doyle,Michelle Christian,Li-Li Wang,Yong Zhang,Clarice Schmidt,Joshua A. Baller,Nikunj V. Somia,Adam J. Bogdanove,Daniel F. Voytas +9 more
TL;DR: A method and reagents for efficiently assembling TALEN constructs with custom repeat arrays are presented and design guidelines based on naturally occurring TAL effectors and their binding sites are described.
Journal ArticleDOI
Targeting DNA Double-Strand Breaks with TAL Effector Nucleases
Michelle Christian,Tomas Cermak,Erin L. Doyle,Clarice Schmidt,Feng Zhang,Aaron W. Hummel,Adam J. Bogdanove,Daniel F. Voytas +7 more
TL;DR: A new class of sequence-specific nucleases created by fusing transcription activator-like effectors (TALEs) to the catalytic domain of the FokI endonuclease is reported.
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Efficient TALEN-mediated gene knockout in livestock
Daniel F. Carlson,Wenfang Tan,Simon G. Lillico,Dana Stverakova,Christopher Proudfoot,Michelle Christian,Daniel F. Voytas,Charles R. Long,C. Bruce A. Whitelaw,Scott C. Fahrenkrug +9 more
TL;DR: TALENs appear to represent a highly facile platform for the modification of livestock genomes for both biomedical and agricultural applications.
Journal ArticleDOI
High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases
Feng Zhang,Morgan L. Maeder,Erica Unger-Wallace,Justin P. Hoshaw,Deepak Reyon,Michelle Christian,Xiaohong Li,Christopher J. Pierick,Drena Dobbs,Thomas Peterson,J. Keith Joung,Daniel F. Voytas +11 more
TL;DR: The high frequency of observed ZFN-induced mutagenesis suggests that targeted mutations can readily be recovered by simply screening progeny of primary transgenic plants by PCR and DNA sequencing.
Journal ArticleDOI
Erratum: Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting (Nucleic Acids Research (2011) 39 (e82) DOI: 10.1093/nar/gkr218)
Tomas Cermak,Erin L. Doyle,Michelle Christian,Li Wang,Yong Zhang,Clarice Schmidt,Joshua A. Baller,Nikunj V. Somia,Adam J. Bogdanove,Daniel F. Voytas +9 more