M
Michelle J Cole
Researcher at Public Health England
Publications - 115
Citations - 4185
Michelle J Cole is an academic researcher from Public Health England. The author has contributed to research in topics: Neisseria gonorrhoeae & Antibiotic resistance. The author has an hindex of 32, co-authored 100 publications receiving 2904 citations. Previous affiliations of Michelle J Cole include European Centre for Disease Prevention and Control & Health Protection Agency.
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Journal ArticleDOI
Prevalence of and factors associated with MDR Neisseria gonorrhoeae in England and Wales between 2004 and 2015: analysis of annual cross-sectional surveillance surveys.
Soazig Clifton,Hikaru Bolt,Hamish Mohammed,Katy Town,Martina Furegato,Michelle J Cole,Oona M. R. Campbell,Helen Fifer,Gwenda Hughes +8 more
TL;DR: Since 2011, a minority of isolates were MDR-NG; however, MICs of azithromycin or ceftriaxone (first-line therapies) for many of these were elevated, highlighting the importance of continued antimicrobial stewardship for gonorrhoea.
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Cysteamine, an Endogenous Aminothiol, and Cystamine, the Disulfide Product of Oxidation, Increase Pseudomonas aeruginosa Sensitivity to Reactive Oxygen and Nitrogen Species and Potentiate Therapeutic Antibiotics against Bacterial Infection
Douglas Fraser-Pitt,Derry K. Mercer,Daniel J. Smith,Aleksandra Kowalczuk,Jennifer M. Robertson,Emma Lovie,Peter Perenyi,Michelle J Cole,Michel Doumith,Robert Hill,Katie L. Hopkins,Neil Woodford,Deborah O'neil +12 more
TL;DR: The therapeutic potentiation of antibiotic therapy against Pseudomonas aeruginosa in mouse models of infection is demonstrated and redox-dependent mechanisms of action for the compound are demonstrated and its antimicrobial effects are shown to be due to undermining bacterial defenses against oxidative and nitrosative challenges.
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Evaluation of the activity of ertapenem against gonococcal isolates exhibiting a range of susceptibilities to cefixime
TL;DR: This study has shown that ertapenem is not a suitable alternative for first-line treatment for gonorrhoea but that it may be useful for the treatment of highly resistant infections.
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Genetic diversity of blaTEM alleles, antimicrobial susceptibility and molecular epidemiological characteristics of penicillinase-producing Neisseria gonorrhoeae from England and Wales
TL;DR: It is encouraging that no further TEM alleles were detected in this gonococcal population; however, vigilance is vital as an ESBL in N. gonorrhoeae would render the last remaining option for monotherapy, ceftriaxone, useless.
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Phylogenomic analysis of Neisseria gonorrhoeae transmission to assess sexual mixing and HIV transmission risk in England: a cross-sectional, observational, whole-genome sequencing study.
Katy Town,Katy Town,Katy Town,Nigel Field,Simon R. Harris,Leonor Sánchez-Busó,Leonor Sánchez-Busó,Michelle J Cole,Rachel Pitt,Helen Fifer,Hamish Mohammed,Gwenda Hughes,Gwenda Hughes +12 more
TL;DR: N gonorrhoeae molecular data can provide information indicating risk of HIV or other sexually transmitted infections for some individuals for whom such risk might not be known from clinical history, and have implications for sexual health care, including offering testing, prevention advice, and preventive treatment, such as HIV pre-exposure prophylaxis.