Michelle J Cole

TL;DR: No genomic evidence was found to explain the differences in clinical outcome for these persistent infections with C. trachomatis and a mutation unrelated to antimicrobial susceptibility was found in an isolate from a persistently infected patient.

TL;DR: In this paper, a new variant of Chlamydia trachomatis (CT) escaped detection in the Hologic Aptima Combo 2 (AC2) assay due to a C1515T mutation in the CT 23S rRNA target region.

TL;DR: The response plan to control and manage multidrug-resistant N. gonorrhoeae (MDR-NG) in Europe was published in 2012 and was updated in 2019 to further support European Union/European Economic Area countries in controlling and managing the threat of MDR/XDR- NG in Europe through further strengthening of AMR surveillance and clinical management including treatment failure monitoring.

TL;DR: Although the rapid increase and spread of decreased susceptibility to cefixime in 2010 has not continued, the detection of isolates with decreases susceptibility to ceftriaxone is concerning.

TL;DR: It is hypothesised that azithromycin exposure provided selection pressure for one or two mutated copies of the 23S rRNA gene to recombine with wild-type copies, leading to 3 to 4 mutated copies in HL-AziR isolates.