M
Michiaki Kohno
Researcher at Gifu Pharmaceutical University
Publications - 24
Citations - 2162
Michiaki Kohno is an academic researcher from Gifu Pharmaceutical University. The author has contributed to research in topics: Mitogen-activated protein kinase & Platelet-derived growth factor receptor. The author has an hindex of 18, co-authored 24 publications receiving 2137 citations. Previous affiliations of Michiaki Kohno include University of Washington & Kyoto University.
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Journal ArticleDOI
Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors
Rika Hoshino,Yuji Chatani,Takao Yamori,Takashi Tsuruo,Takashi Tsuruo,Hiroya Oka,Osamu Yoshida,Yutaka Shimada,Shigeki Arii,Hiromi Wada,Jiro Fujimoto,Michiaki Kohno +11 more
TL;DR: The results suggest that the constitutive activation of 41-/43-kDa MAP kinases in tumor cells is not due to the disorder of MAP kinase themselves, but is due toThe disorder of Raf-1, Ras, or some other signaling molecules upstream of Ras.
Journal Article
Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinoma.
Hiroya Oka,Yuji Chatani,Rika Hoshino,Osamu Ogawa,Yoshiyuki Kakehi,Toshiro Terachi,Yusaku Okada,Masashi Kawaichi,Michiaki Kohno,Osamu Yoshida +9 more
TL;DR: The results suggest that constitutive activation of MAPKs may be associated with the carcinogenesis of human RCCs.
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Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2.
TL;DR: The results clearly indicate that activation of the p38 MAP kinase pathway is necessary for BMP-2-induced neuronal differentiation of PC12 cells and suggest thatactivation of thep38 MAP Kinase pathway alone can induce the neuronal differentiate of PC 12 cells.
Journal ArticleDOI
Tumor necrosis factor stimulates the synthesis and secretion of biologically active nerve growth factor in non-neuronal cells.
Akira Hattori,Eiko Tanaka,Katsuhito Murase,Nobuhiro Ishida,Yuji Chatani,Masafumi Tsujimoto,Kyozo Hayashi,Michiaki Kohno +7 more
TL;DR: It is suggested that TNF plays a role in regulating neuronal cell function through an indirect mechanism by which it stimulates NGF production in glial cells and fibroblasts.
Journal ArticleDOI
Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering
Susumu Tanimura,Susumu Tanimura,Yuji Chatani,Rika Hoshino,Masahiro Sato,Shin-ichi Watanabe,Tadashi Kataoka,Toshikazu Nakamura,Michiaki Kohno,Michiaki Kohno +9 more
TL;DR: In this paper, the authors showed that activation of the 41/43 kDa MAP kinase signaling pathway is required for motility response of MDCK and TMK1 cells induced by agents such as HGF, PMA and EGF.