M
Michiel Kleerebezem
Researcher at Wageningen University and Research Centre
Publications - 311
Citations - 38778
Michiel Kleerebezem is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Lactococcus lactis & Lactobacillus plantarum. The author has an hindex of 93, co-authored 301 publications receiving 33750 citations. Previous affiliations of Michiel Kleerebezem include Netherlands Bioinformatics Centre.
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Journal ArticleDOI
Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria
Peter A. Bron,Barbara Marcelli,Joyce Mulder,Simon van der Els,Luiza P. Morawska,Oscar P. Kuipers,Jan Kok,Michiel Kleerebezem +7 more
TL;DR: The possibilities for industrial strain improvement arising from the recent discoveries of molecular exchanges between bacteria through nanotubes and extracellular vesicles, as well as the constantly expanding genome editing possibilities using the CRISPR-Cas technology are envisioned.
Journal ArticleDOI
Lactic Acid Bacteria: embarking on 30 more years of research.
TL;DR: The breadth and richness of LAB research is exemplified by the six selected scientific areas that will be covered at the LAB11 Symposium: Diversity and Evo- lution; Genetics and Physiology; Ecosystems and Sus- tainability; Fermentation and Industrial Application; Host-Microbe Interactions; and Emerging Technologies.
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Two Arginine Repressors Regulate Arginine Biosynthesis in Lactobacillus plantarum
Hervé Nicoloff,Florence Arsène-Ploetze,Cédric Malandain,Michiel Kleerebezem,Françoise Bringel +4 more
TL;DR: Twenty mutants have lost their ability to grow in normal air without carbon dioxide enrichment; this revealed a link between arginine biosynthesis and a still-unknown CO2-dependent metabolic pathway.
Journal ArticleDOI
Regulatory Phenotyping Reveals Important Diversity within the Species Lactococcus lactis
Herwig Bachmann,Marjo J. C. Starrenburg,Annereinou Dijkstra,Douwe Molenaar,Michiel Kleerebezem,J. L. W. Rademaker,J.E.T. van Hylckama Vlieg +6 more
TL;DR: The presented findings underline the importance of the availability of screening procedures for, e.g., industrially relevant enzyme activities in models closely mimicking application conditions and corroborate the notion that regulatory changes are important drivers of evolution.
Journal ArticleDOI
Lactobacillus strains differentially modulate cytokine production by hPBMC from pollen-allergic patients.
Yvonne M. Vissers,Johannes Snel,Peter F. Zuurendonk,Michiel Kleerebezem,Harry J. Wichers,Huub F. J. Savelkoul +5 more
TL;DR: Assessing the potential immunomodulatory effect of six Lactobacillus strains on human peripheral blood mononuclear cells isolated from allergic patients found that suppression of the T-helper type 2 (Th2) cytokine induction and induction of the Th1 cytokine production by specific strains might be beneficial for allergic patients having a disturbed Th1/Th2 immune balance.