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Michiel Kleerebezem

Researcher at Wageningen University and Research Centre

Publications -  311
Citations -  38778

Michiel Kleerebezem is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Lactococcus lactis & Lactobacillus plantarum. The author has an hindex of 93, co-authored 301 publications receiving 33750 citations. Previous affiliations of Michiel Kleerebezem include Netherlands Bioinformatics Centre.

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Renaissance of traditional DNA transfer strategies for improvement of industrial lactic acid bacteria

TL;DR: The possibilities for industrial strain improvement arising from the recent discoveries of molecular exchanges between bacteria through nanotubes and extracellular vesicles, as well as the constantly expanding genome editing possibilities using the CRISPR-Cas technology are envisioned.
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Lactic Acid Bacteria: embarking on 30 more years of research.

TL;DR: The breadth and richness of LAB research is exemplified by the six selected scientific areas that will be covered at the LAB11 Symposium: Diversity and Evo- lution; Genetics and Physiology; Ecosystems and Sus- tainability; Fermentation and Industrial Application; Host-Microbe Interactions; and Emerging Technologies.
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Two Arginine Repressors Regulate Arginine Biosynthesis in Lactobacillus plantarum

TL;DR: Twenty mutants have lost their ability to grow in normal air without carbon dioxide enrichment; this revealed a link between arginine biosynthesis and a still-unknown CO2-dependent metabolic pathway.
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Regulatory Phenotyping Reveals Important Diversity within the Species Lactococcus lactis

TL;DR: The presented findings underline the importance of the availability of screening procedures for, e.g., industrially relevant enzyme activities in models closely mimicking application conditions and corroborate the notion that regulatory changes are important drivers of evolution.
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Lactobacillus strains differentially modulate cytokine production by hPBMC from pollen-allergic patients.

TL;DR: Assessing the potential immunomodulatory effect of six Lactobacillus strains on human peripheral blood mononuclear cells isolated from allergic patients found that suppression of the T-helper type 2 (Th2) cytokine induction and induction of the Th1 cytokine production by specific strains might be beneficial for allergic patients having a disturbed Th1/Th2 immune balance.