M
Michiel Kleerebezem
Researcher at Wageningen University and Research Centre
Publications - 311
Citations - 38778
Michiel Kleerebezem is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Lactococcus lactis & Lactobacillus plantarum. The author has an hindex of 93, co-authored 301 publications receiving 33750 citations. Previous affiliations of Michiel Kleerebezem include Netherlands Bioinformatics Centre.
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The predicted secretome of Lactobacillus plantarum WCFS1 sheds light on interactions with its environment.
TL;DR: The functional annotation of extracellular proteins was improved using a wide variety of bioinformatics methods, including domain analysis and phylogenetic profiling, to gain insight into the mechanisms underlying interactions of this bacterium with its environment.
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High-fat feeding rather than obesity drives taxonomical and functional changes in the gut microbiota in mice.
Liang Xiao,Si Brask Sonne,Qiang Feng,Ning Chen,Zhongkui Xia,Xiaoping Li,Zhiwei Fang,Dongya Zhang,Even Fjære,Even Fjære,Lisa Kolden Midtbø,Lisa Kolden Midtbø,Muriel Derrien,Floor Hugenholtz,Longqing Tang,Junhua Li,Jianfeng Zhang,Liu Chuan,Qin Hao,Ulla Vogel,Alicja Mortensen,Michiel Kleerebezem,Tine Rask Licht,Huanming Yang,Jian Wang,Yingrui Li,Manimozhiyan Arumugam,Jun Wang,Lise Madsen,Lise Madsen,Karsten Kristiansen +30 more
TL;DR: Differences in the abundance of butyrate and propionate producing bacteria in the gut may at least in part contribute to the observed differences in obesity propensity in Sv129 and BL6 mice.
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Functional Analysis of Three Plasmids from Lactobacillus plantarum
Richard van Kranenburg,Natasa Golic,Roger S. Bongers,R.J. Leer,Willem M. de Vos,Roland J. Siezen,Michiel Kleerebezem +6 more
TL;DR: Plasmid pWCFS103 was demonstrated to be a conjugative plasmid, as it could be transferred to L. plantarum NC8 and confers arsenate and arsenite resistance, which can be used as selective markers.
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Metabolic engineering of lactic acid bacteria: overview of the approaches and results of pathway rerouting involved in food fermentations.
TL;DR: There have been recent successes in metabolic engineering in these lactic acid bacteria, including examples of changes in both primary metabolism (diacetyl and alanine) and secondary metabolism (exopolysaccharides and flavour).
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Spatial and temporal expression of Lactobacillus plantarum genes in the gastrointestinal tracts of mice.
TL;DR: Results confirm that L. plantarum displays specific and differential responses at various sites along the mammalian intestine.