M
Mie Nakaya
Researcher at Massachusetts Institute of Technology
Publications - 5
Citations - 1613
Mie Nakaya is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Guanine nucleotide exchange factor & Rap1. The author has an hindex of 4, co-authored 5 publications receiving 1570 citations.
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Journal ArticleDOI
A family of cAMP-binding proteins that directly activate Rap1.
Hiroaki Kawasaki,Gregory M. Springett,Naoki Mochizuki,Shinichiro Toki,Mie Nakaya,Michiyuki Matsuda,David E. Housman,Ann M. Graybiel +7 more
TL;DR: The findings suggest the need to reformulate concepts of cAMP-mediated signaling to include direct coupling to Ras superfamily signaling.
Journal ArticleDOI
Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504.
Tamotsu Ichiba,Tamotsu Ichiba,Yuko Hashimoto,Mie Nakaya,Yasunobu Kuraishi,Shinya Tanaka,Takeshi Kurata,Naoki Mochizuki,Michiyuki Matsuda +8 more
TL;DR: C3G is a guanine nucleotide exchange factor for Rap1 and is activated by the expression of Crk adaptor proteins and CrkI activates C3G by the phosphorylation of tyrosine 504, which represses thecis-acting negative regulatory domain outside the catalytic region.
Journal ArticleDOI
Rap2 as a Slowly Responding Molecular Switch in the Rap1 Signaling Cascade
Yusuke Ohba,Naoki Mochizuki,Keiko Matsuo,Shigeko Yamashita,Mie Nakaya,Yuko Hashimoto,Michinari Hamaguchi,Takeshi Kurata,Kazuo Nagashima,Michiyuki Matsuda +9 more
TL;DR: GTP-Rap2 is regulated by a similar set of GEFs and GAPs as Rap1 and functions as a slowly responding molecular switch in the Rap1 signaling cascade.
Journal ArticleDOI
Inhibition of human immunodeficiency virus type 1 virion entry by dominant-negative Hck
Kenzo Tokunaga,Kenzo Tokunaga,Etsuko Kiyokawa,Mie Nakaya,Naomi Otsuka,Asato Kojima,Takeshi Kurata,Michiyuki Matsuda +7 more
TL;DR: An Hck mutant, HckN, that hinders signaling from wild-type Hck is constructed that suggests that the Src family tyrosine kinases regulate entry of HIV-1 into target cells.
Journal ArticleDOI
Epidermal growth factor-dependent dissociation of CrkII proto-oncogene product from the epidermal growth factor receptor in human glioma cells.
Haruko Katayama,Yuko Hashimoto,Etsuko Kiyokawa,Mie Nakaya,Atsuhiko Sakamoto,Rikuo Machinami,Takeshi Kurata,Naoki Mochizuki,Michiyuki Matsuda +8 more
TL;DR: EGF‐dependent binding of CrkII to phosphotyrosine‐containing proteins appears to be suppressed in glioma cells, which implicate EGF‐ dependence on EGFR dissociation in the oncogenicity of human gliomas cells.