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Yusuke Ohba
Researcher at Hokkaido University
Publications - 129
Citations - 17590
Yusuke Ohba is an academic researcher from Hokkaido University. The author has contributed to research in topics: Signal transduction & Guanine nucleotide exchange factor. The author has an hindex of 42, co-authored 121 publications receiving 15841 citations. Previous affiliations of Yusuke Ohba include National Presto Industries & University of Tokyo.
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Journal ArticleDOI
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Koji Atarashi,Takeshi Tanoue,Tatsuichiro Shima,Akemi Imaoka,Tomomi Kuwahara,Yoshika Momose,Genhong Cheng,Sho Yamasaki,Takashi Saito,Yusuke Ohba,Tadatsugu Taniguchi,Kiyoshi Takeda,Shohei Hori,Ivaylo I. Ivanov,Yoshinori Umesaki,Kikuji Itoh,Kenya Honda,Kenya Honda +17 more
TL;DR: Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.
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IRF-7 is the master regulator of type-I interferon-dependent immune responses
Kenya Honda,Hideyuki Yanai,Hideo Negishi,Masataka Asagiri,Mitsuharu Sato,Tatsuaki Mizutani,Naoya Shimada,Yusuke Ohba,Yusuke Ohba,Akinori Takaoka,Nobuaki Yoshida,Tadatsugu Taniguchi +11 more
TL;DR: It is shown that mice deficient in the Irf7 gene are more vulnerable than Myd88-/- mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the importance of the IRF-7-dependent induction of systemic IFN responses for innate antiviral immunity.
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DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
Akinori Takaoka,ZhiChao Wang,Myoung Kwon Choi,Hideyuki Yanai,Hideo Negishi,Tatsuma Ban,Yan Lu,Makoto Miyagishi,Tatsuhiko Kodama,Kenya Honda,Yusuke Ohba,Tadatsugu Taniguchi +11 more
TL;DR: The artificial expression of otherwise IFN-inducible DAI (DLM-1/ZBP1) in mouse fibroblasts selectively enhances the DNA-mediated induction of type I IFN and other genes involved in innate immunity, and may offer new insight into the signalling mechanisms underlying DNA-associated antimicrobial immunity and autoimmune disorders.
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Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
Akinori Takaoka,Hideyuki Yanai,Seiji Kondo,Gordon S. Duncan,Hideo Negishi,Tatsuaki Mizutani,Shin Ichi Kano,Kenya Honda,Yusuke Ohba,Tak W. Mak,Tadatsugu Taniguchi +10 more
TL;DR: The transcription factor IRF-5 is identified as a new, principal downstream regulator of the TLR–MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses.
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Apoptosis and Molecular Targeting Therapy in Cancer
TL;DR: The main regulatory molecules that govern the main basic mechanisms, extrinsic and intrinsic, of apoptosis in normal cells are provided and how carcinogenesis could be developed via defective apoptotic pathways or their convergence is discussed.