Mieke Roosen

TL;DR: A culture system for bladder cancer based on organoid culture technology is presented and a living biobank containing organoids grown from over 50 patient samples is created, which reflects many aspects of bladder cancer pathogenesis.

TL;DR: A comprehensive overview of all the different reported oncogenic fusion proteins in pediatric central nervous system (CNS) neoplasms is still lacking as discussed by the authors . But, a better understanding of the fusion proteins detected in these tumors and of the molecular mechanisms how these proteins drive tumorigenesis, could improve diagnosis and further benefit translational research into targeted therapies necessary to treat these distinct entities.

TL;DR: In this paper , the authors measured inflammation and platelet and neutrophil activation markers in patients with cerebral small vessel disease (cSVD) and age-matched controls to identify potential novel biomarkers for cSVD, gaining new insights into its pathophysiology.

TL;DR: Different organoid models of TP53-mutated SHH MB will enable us to find more effective treatments and to better understand how to treat patients with different mutation combinations, and initial safety of drugs on cerebellar cells can be assessed.