M
Miguel R. Abboud
Researcher at American University of Beirut
Publications - 241
Citations - 9784
Miguel R. Abboud is an academic researcher from American University of Beirut. The author has contributed to research in topics: Sickle cell anemia & Stroke. The author has an hindex of 43, co-authored 227 publications receiving 8730 citations. Previous affiliations of Miguel R. Abboud include Indiana University – Purdue University Indianapolis & Indiana University.
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Journal ArticleDOI
Prevention of a First Stroke by Transfusions in Children with Sickle Cell Anemia and Abnormal Results on Transcranial Doppler Ultrasonography
Robert J. Adams,Virgil McKie,Lewis L. Hsu,B Files,Elliott Vichinsky,Charles H. Pegelow,Miguel R. Abboud,Dianne Gallagher,Abdullah Kutlar,Fenwick T. Nichols,Duane Bonds,Donald Brambilla +11 more
TL;DR: Transfusion greatly reduces the risk of a first stroke in children with sickle cell anemia who have abnormal results on transcranial Doppler ultrasonography.
Journal ArticleDOI
A Comparison of Conservative and Aggressive Transfusion Regimens in the Perioperative Management of Sickle Cell Disease
E. Vichinsky,Charles M. Haberkern,Lynne Neumayr,A. Earles,Dennis Black,Mabel Koshy,Charles H. Pegelow,Miguel R. Abboud,Kwaku Ohene-Frempong,Rathi V. Iyer +9 more
TL;DR: A conservative transfusion regimen was as effective as an aggressive regimen in preventing perioperative complications in patients with sickle cell anemia, and the conservative approach resulted in only half as many transfusion-associated complications.
Journal ArticleDOI
Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity
Christian Braun,Kaan Boztug,Anna Paruzynski,Maximilian Witzel,Adrian Schwarzer,Michael Rothe,Ute Modlich,Rita Beier,Gudrun Göhring,Doris Steinemann,Raffaele Fronza,Claudia R. Ball,Reinhard Haemmerle,Sonja Naundorf,Klaus Kühlcke,Martina Rose,Chris Fraser,Liesl Mathias,Rudolf Ferrari,Miguel R. Abboud,Waleed Al-Herz,Irina Kondratenko,László Maródi,Hanno Glimm,Brigitte Schlegelberger,Axel Schambach,Michael H. Albert,Manfred Schmidt,Christof von Kalle,Christoph Klein +29 more
TL;DR: It is suggested that with improved vector design, gene therapy may be feasible and effective for patient with Wiskott-Aldrich syndrome, and the use of γ-retroviral vectors is associated with a substantial risk of leukemogenesis.
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Effects of Recombinant Human Granulocyte Colony-Stimulating Factor on Neutropenia in Patients with Congenital Agranulocytosis
Mary Ann Bonilla,Alfred P. Gillio,Mary Ruggeiro,Nancy A. Kernan,Joel A. Brochstein,Miguel R. Abboud,Luca Fumagalli,Martha Vincent,Janice Gabrilove,Karl Welte,Lawrence M. Souza,Richard J. O'Reilly +11 more
TL;DR: Treatment with rhG-CSF can lead to a large increase in the numbers of functional neutrophils in patients with congenital agranulocytosis, and the number of new infectious episodes and the requirement for intravenous antibiotics have decreased.
Journal ArticleDOI
Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions.
Charles H. Pegelow,Robert J. Adams,Virgil McKie,Miguel R. Abboud,Brian Berman,Scott T. Miller,Nancy F. Olivieri,Elliott Vichinsky,Winfred C. Wang,Donald Brambilla +9 more
TL;DR: It is concluded that maintenance of hemoglobin S at a level less than 30% appears to be effective in reducing the rate of recurrent infarction but does not prevent transient neurologic events.