A
A. Earles
Researcher at Children's Hospital Oakland
Publications - 17
Citations - 3775
A. Earles is an academic researcher from Children's Hospital Oakland. The author has contributed to research in topics: Sickle cell anemia & Acute chest syndrome. The author has an hindex of 13, co-authored 17 publications receiving 3504 citations. Previous affiliations of A. Earles include Children's Hospital Oakland Research Institute.
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Journal ArticleDOI
Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease
Elliott Vichinsky,Lynne Neumayr,A. Earles,Roger Williams,Evelyne T. Lennette,Deborah Dean,Bruce G. Nickerson,Eugene P. Orringer,Virgil McKie,Rita Bellevue,Charles Daeschner,E A Manci +11 more
TL;DR: A treatment protocol that included matched transfusions, bronchodilators, and bronchoscopy was evaluated and it was found that infection and fat embolism are underdiagnosed in patients with the syndrome.
Journal ArticleDOI
A Comparison of Conservative and Aggressive Transfusion Regimens in the Perioperative Management of Sickle Cell Disease
E. Vichinsky,Charles M. Haberkern,Lynne Neumayr,A. Earles,Dennis Black,Mabel Koshy,Charles H. Pegelow,Miguel R. Abboud,Kwaku Ohene-Frempong,Rathi V. Iyer +9 more
TL;DR: A conservative transfusion regimen was as effective as an aggressive regimen in preventing perioperative complications in patients with sickle cell anemia, and the conservative approach resulted in only half as many transfusion-associated complications.
Journal ArticleDOI
Alloimmunization in sickle cell anemia and transfusion of racially unmatched blood.
TL;DR: It is concluded that alloimmunization is a common, clinically serious problem in sickle cell anemia and that it is partly due to racial differences between the blood-donor and recipient populations.
Journal ArticleDOI
The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up
Martin H. Steinberg,William F. McCarthy,Oswaldo Castro,Samir K. Ballas,F. Danny Armstrong,Wally R. Smith,Kenneth I. Ataga,Paul Swerdlow,Abdullah Kutlar,Laura DeCastro,Myron A. Waclawiw,Eugene P. Orringer,Susan Jones,D. Strayhorn,Wendell F. Rosse,George Phillips,D. Peace,A. Johnson-Telfair,Lisa Daitch,Paul F. Milner,A. Tracy,S. Valdez,G. E. Allen,J. Moshang,B. Scott,Carolyn Bigelow,A. Anderson,V. Sabahi,T. Harrington,W. Labrousse,Charles H. Pegelow,D. Temple,E. Case,R. Harrell,S. Childerie,Stephen H. Embury,B. Schmidt,D. Davies,Yogen Saunthararajah,Mabel Koshy,N. Talischy-Zahed,L. Dorn,G. Pendarvis,M. McGee,Margaret Telfer,A. Davis,O. C. Onyekwere,C. Nwokolo,Helga Finke,Elliott Perlin,J. Siteman,M. Bryan,T. Saunders,Y. Barber,P. Gascon,P. Di Paolo,S. Gargiulo,James R. Eckman,E. Carter-Randall,J. H. Bailey,A. Platt,L. Waller,G. Ramirez,V. Knors,S. Hernandez,E. M. Rodriguez,E. Wilkes,Elliott Vichinsky,Ward Hagar,C. Hoehner,E. Hackney-Stevens,S. Claster,A. Earles,K. Kleman,K. McLaughlin,L. White,B. Maddox,L. Usry,A. Brenner,K. Williams,R. O'Brien,K. Genther,Susan B. Shurin,Brian W. Berman,K. Chiarucci,L. Keverline,Nancy F. Olivieri,J. Chow,M. Hui,D. Shaw,N. Lewis,Maureen Okam,Elyse Mandell,A. Palmer,Kenneth Bridges,B. Tynan,C. Winograd,Rita Bellevue,Harvey Dosik,M. Sheikhai,P. Ryans,H. Souffrant,Brian Adler,L. Eskridge,Josef T. Prchal,J. Braddock,T. McArdle,Timothy M. Carlos,A. Roundtree-Schmotzer,D. Gardner +109 more
TL;DR: It is suggested that long‐term use of hydroxyurea is safe and might decrease mortality, while no longer the product of a randomized study because of the ethical concerns of withholding an efficacious treatment.
Journal ArticleDOI
Newborn Screening for Sickle Cell Disease: Effect on Mortality
TL;DR: Ten years of experience in newborn screening for sickle cell disease have been summarized and hemoglobinopathies are the most prevalent congenital disease.