Kristiina Järvinen

TL;DR: Ocular absorption of topically applied ophthalmic drugs is limited by rapid precorneal drug elimination due to solution drainage and systemic absorption from the conjunctival sac, and another factor that limits ocular absorption is the corneal epithelial barrier.

TL;DR: It was demonstrated that by enclosing the functionalized protein coated itraconazole nanoparticles to the external nanofibrillar cellulose matrix notably increased their storage stability and enhanced the in vivo performance of the drug.

TL;DR: Three-step tumor targeting of paclitaxel using biotinylated PLA-PEG nanoparticles and avidin-biotin technology was evaluated in vitro to indicate that the efficacy of pac litaxel against tumor cells can be increased by this three-step targeting method.

TL;DR: It is suggested that THCPSi might be used as a drug delivery system for peptides with a high loading degree with the aim of prolonging peptide action after their administration.

TL;DR: In this article, the authors compared the usefulness, advantages and disadvantages of seven methods that are widely used to detect, and quantify the amorphous contents in pharmaceutical solids, including X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), stepScan DSC (SS-DSC).