M
Mikael S. Lindström
Researcher at Karolinska Institutet
Publications - 51
Citations - 3443
Mikael S. Lindström is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Ribosome biogenesis & Ribosomal protein. The author has an hindex of 29, co-authored 47 publications receiving 3008 citations. Previous affiliations of Mikael S. Lindström include Karolinska University Hospital & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling.
TL;DR: It is argued that the suggested function of NPM1 as a histone chaperone could explain several, but not all, of the effects observed in cells following changes in N PM1 expression.
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Targeted Inactivation of Mdm2 RING Finger E3 Ubiquitin Ligase Activity in the Mouse Reveals Mechanistic Insights into p53 Regulation
Koji Itahana,Hua Mao,Aiwen Jin,Yoko Itahana,Hilary V. Clegg,Mikael S. Lindström,Krishna P. Bhat,Virginia Godfrey,Gerard I. Evan,Yanping Zhang +9 more
TL;DR: The data indicate that the MDM2-p53 physical interaction, without Mdm2-mediated p53 ubiquitination, cannot control p53 activity sufficiently to allow early mouse embryonic development, and (2) Mdm1's E3 function is not required for Mdm 2 degradation.
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An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction.
Everardo Macias,Aiwen Jin,Chad Deisenroth,Krishna P. Bhat,Hua Mao,Mikael S. Lindström,Yanping Zhang +6 more
TL;DR: These findings establish RP-Mdm2 interaction as a genuine p53 stress-signaling pathway activated by aberrant ribosome biogenesis and essential for safeguarding against oncogenic c-MYC-induced tumorigenesis.
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Emerging functions of ribosomal proteins in gene-specific transcription and translation.
TL;DR: Findings suggest that ribosomal proteins may have a wider functional repertoire within the cell than previously thought and the future challenge is to identify and validate these novel functions in the background of an often essential primary function in ribosome biogenesis and cell growth.
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Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis.
TL;DR: The focus will be on features of rDNA genes, which make them highly vulnerable to DNA damage and intra- and interchromosomal recombination as well as built-in mechanisms that prevent and repair rDNA damage, and how dysregulation of this interplay affects genome-wide DNA stability, gene expression and the balance between euchromatin and heterochromatin.