Sladana Bursac

TL;DR: It is reported that the disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53activation by ribosomal biogenesis stress.

TL;DR: The focus will be on features of rDNA genes, which make them highly vulnerable to DNA damage and intra- and interchromosomal recombination as well as built-in mechanisms that prevent and repair rDNA damage, and how dysregulation of this interplay affects genome-wide DNA stability, gene expression and the balance between euchromatin and heterochromatin.

TL;DR: Recent advances made toward understanding of this newly-recognized checkpoint signaling pathway, its role in health and disease, and possible future directions in this exciting research field are reviewed.

TL;DR: In human oncogene-transformed and cancer cells, ATM suppressed ARF protein levels and activity in a transcription-independent manner and inhibition of ATM stimulated the tumour-suppressive effects of ARF.

TL;DR: In this paper, a high-content siRNA-based screen of 175 human ribosome biogenesis factors, searching for impact on p53, was performed and it was shown that WDR75 is required for pre-rRNA transcription through supporting the maintenance of physiological levels of RPA194, a key subunit of the RNA polymerase I.