Ines Orsolic

TL;DR: It is reported that the disrupted nucleoli may provide a platform for L5- and L11-dependent p53 activation, implying a role for the nucleolus in p53activation by ribosomal biogenesis stress.

TL;DR: The focus will be on features of rDNA genes, which make them highly vulnerable to DNA damage and intra- and interchromosomal recombination as well as built-in mechanisms that prevent and repair rDNA damage, and how dysregulation of this interplay affects genome-wide DNA stability, gene expression and the balance between euchromatin and heterochromatin.

TL;DR: The fact that dysregulation of many of these fundamental cellular processes may contribute to the malignant phenotype suggests that normal functioning of the nucleolus safeguards against the development of cancer and indicates its potential as a therapeutic approach.

TL;DR: In human oncogene-transformed and cancer cells, ATM suppressed ARF protein levels and activity in a transcription-independent manner and inhibition of ATM stimulated the tumour-suppressive effects of ARF.

TL;DR: It is proposed that, in cells in which activated oncogenes drive excessive protein synthesis, FGF13 may favor survival by maintaining translation rates at a level compatible with the protein quality-control capacity of the cell.