M
Mikhail A. Sovershaev
Researcher at University of Tromsø
Publications - 33
Citations - 1327
Mikhail A. Sovershaev is an academic researcher from University of Tromsø. The author has contributed to research in topics: Tissue factor & Lung injury. The author has an hindex of 17, co-authored 33 publications receiving 1227 citations. Previous affiliations of Mikhail A. Sovershaev include University Hospital of North Norway.
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Journal ArticleDOI
Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study.
Mikhail Y. Kirov,Oleg V. Evgenov,Natalia V. Evgenov,Elena M. Egorina,Mikhail A. Sovershaev,Baldur Sveinbjørnsson,Eduard V. Nedashkovsky,Lars J. Bjertnaes +7 more
TL;DR: In human septic shock, continuously infused MB counteracts myocardial depression, maintains oxygen transport, and reduces concurrent adrenergic support, and Infusion of MB appears to have no significant adverse effects on the selected organ function variables.
Journal ArticleDOI
Extravascular lung water determined with single transpulmonary thermodilution correlates with the severity of sepsis-induced acute lung injury.
Vsevolod V. Kuzkov,Mikhail Y. Kirov,Mikhail A. Sovershaev,Vladimir N. Kuklin,Suborov Ev,Kristine Waerhaug,Lars J. Bjertnaes +6 more
TL;DR: In human septic shock, EVLWI demonstrated moderate correlation with markers of acute lung injury, such as lung compliance, oxygenation ratio, roentgenogram quadrants, and lung injury score, which might be of value as an indicator of prognosis and severity of sepsis-induced acute lung Injury.
Journal ArticleDOI
Intracellular and Surface Distribution of Monocyte Tissue Factor. Application to Intersubject Variability
Elena M. Egorina,Mikhail A. Sovershaev,Geir Bjørkøy,Franz Gruber,Jan Ole Olsen,Behnaz Parhami-Seren,Kenneth G. Mann,Bjarne Østerud +7 more
TL;DR: The higher availability of surface TF antigen on MNCs from HRs and TF-containing microparticles might make these individuals more susceptible to hypercoagulation.
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Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer
TL;DR: Together, monocytes are pinpointed as a major source of TF and solid experimental evidence for a direct transfer of TF protein from the monocytes to granulocytes in the blood is provided.
Journal ArticleDOI
Endothelial Dysfunction Enhances Vasoconstriction Due to Scavenging of Nitric Oxide by a Hemoglobin-based Oxygen Carrier
Binglan Yu,Mohd Shahid,Elena M. Egorina,Mikhail A. Sovershaev,Michael J. Raher,Chong Lei,Mei X. Wu,Kenneth D. Bloch,Warren M. Zapol +8 more
TL;DR: Reduction in low molecular weight hemoglobin concentrations to less than 1% is insufficient to abrogate the vasoconstrictor effects of HBOC infusion in healthy awake sheep or in mice with reduced vascular nitric oxide levels associated with endothelial dysfunction.