M
Mildred Wilson
Researcher at National Institutes of Health
Publications - 14
Citations - 1696
Mildred Wilson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Tumor necrosis factor alpha & B cell. The author has an hindex of 10, co-authored 14 publications receiving 1577 citations.
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Journal ArticleDOI
TNF downmodulates the function of human CD4+CD25hi T-regulatory cells.
Xavier Valencia,Geoffrey L. Stephens,Raphaela Goldbach-Mansky,Mildred Wilson,Ethan M. Shevach,Peter E. Lipsky +5 more
TL;DR: TNF has a novel action in modulating autoimmunity, by inhibiting CD4+CD25+ Treg activity, through signaling through TNFRII that is constitutively expressed selectively on unstimulated Tregs and that is up-regulated by TNF.
Journal ArticleDOI
A pilot study to evaluate the safety and efficacy of the long-acting interleukin-1 inhibitor rilonacept (interleukin-1 trap) in patients with familial cold autoinflammatory syndrome†
Raphaela Goldbach-Mansky,Sharukh D. Shroff,Mildred Wilson,Christopher Snyder,Sara Plehn,Beverly K. Barham,Tuyet-Hang Pham,Frank Pucino,Robert Wesley,Joanne Papadopoulos,Steven P. Weinstein,Scott Mellis,Daniel L. Kastner +12 more
TL;DR: The dramatic improvement in clinical and laboratory measures of inflammation, the sustained response, and the good tolerability suggest that this drug may be a promising therapeutic option in patients with FCAS and the data led to the design of a phase III study in this patient population.
Journal ArticleDOI
Comparison of Tripterygium wilfordii Hook F Versus Sulfasalazine in the Treatment of Rheumatoid Arthritis: A Randomized Trial
Raphaela Goldbach-Mansky,Mildred Wilson,Roy Fleischmann,Nancy J. Olsen,Joel Silverfield,Phillip Kempf,Alan Kivitz,Yvonne Sherrer,Frank Pucino,Gyorgy Csako,Rene Costello,T. Pham,Christopher Snyder,Désirée van der Heijde,Xuelian Tao,Robert Wesley,Peter E. Lipsky +16 more
TL;DR: Extracts of the medicinal plant Tripterygium wilfordii Hook F (TwHF) have been used in China for centuries to treat a spectrum of inflammatory diseases as mentioned in this paper.
Journal Article
Comparison of Tripterygium wilfordii Hook F Versus Sulfasalazine in the Treatment of Rheumatoid Arthritis
Raphaela Goldbach-Mansky,Mildred Wilson,Roy Fleischmann,Nancy J. Olsen,Joel Silverfield,Phillip Kempf,Alan Kivitz,Yvonne Sherrer,Frank Pucino,Gyorgy Csako,Rene Costello,T. Pham,Christopher Snyder,Xuelian Tao,Robert Wesley,Peter E. Lipsky,Fort Lauderdale +16 more
TL;DR: This trial compared TwHF extract with sulfasalazine in 121 patients with active rheumatoid arthritis who could continue oral prednisone and nonsteroidal anti-inflammatory drugs but not disease-modifying antirheumatic drugs.
Journal ArticleDOI
Alterations in peripheral blood memory B cells in patients with active rheumatoid arthritis are dependent on the action of tumour necrosis factor
M. Margarida Souto-Carneiro,Vijayabhanu Mahadevan,Kazuki Takada,Ruth D E Fritsch-Stork,Toshihiro Nanki,Margaret R. Brown,Thomas A. Fleisher,Mildred Wilson,Raphaela Goldbach-Mansky,Peter E. Lipsky +9 more
TL;DR: The data suggest that decreases in peripheral blood IgD+CD27+ pre-switch memory B cells in RA reflect their accumulation in the synovial tissue, and indicates that trafficking ofMemory B cells into inflamed tissue in RA patients is regulated by TNF and can be corrected by neutralising TNF.