M
Milena Casula
Researcher at National Research Council
Publications - 61
Citations - 1839
Milena Casula is an academic researcher from National Research Council. The author has contributed to research in topics: Melanoma & Cancer. The author has an hindex of 22, co-authored 56 publications receiving 1626 citations. Previous affiliations of Milena Casula include Carlos III Health Institute & Yahoo!.
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Journal ArticleDOI
BRAF/NRAS Mutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma
Maria Colombino,Mariaelena Capone,Amelia Lissia,Antonio Cossu,Corrado Rubino,Vincenzo De Giorgi,Daniela Massi,Ester Fonsatti,Stefania Staibano,Oscar Nappi,Elena Pagani,Milena Casula,Antonella Manca,MariaCristina Sini,Renato Franco,Gerardo Botti,Corrado Caracò,Nicola Mozzillo,Paolo A. Ascierto,Giuseppe Palmieri +19 more
TL;DR: The findings about the prevalence of BRAF/NRAS/p16CDKN2A mutations in paired tumor lesions from patients with melanoma may be useful in the management of this disease.
Journal ArticleDOI
Main roads to melanoma
Giuseppe Palmieri,Mariaelena Capone,Maria Libera Ascierto,Giusy Gentilcore,David F. Stroncek,Milena Casula,Maria Cristina Sini,Marco Palla,Nicola Mozzillo,Paolo A. Ascierto +9 more
TL;DR: All evidence clearly indicates the existence of a complex molecular machinery that provides checks and balances in normal melanocytes, which is the result of a combination of down- or up-regulation of various effectors acting on different molecular pathways.
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Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets
Giuseppe Palmieri,MariaNeve Ombra,Maria Colombino,Milena Casula,MariaCristina Sini,Antonella Manca,Panagiotis Paliogiannis,Paolo A. Ascierto,Antonio Cossu +8 more
TL;DR: The known molecular mechanisms underlying either intrinsic and acquired drug resistance either alternative roads to melanoma pathogenesis, which may become targets for innovative anticancer approaches are summarized.
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BRCA1 and BRCA2 point mutations and large rearrangements in breast and ovarian cancer families in Northern Poland.
Magdalena Ratajska,Izabela Brozek,Elżbieta Senkus-Konefka,Jacek Jassem,Magdalena Stepnowska,Grazia Palomba,Marina Pisano,Milena Casula,Giuseppe Palmieri,Åke Borg,Janusz Limon +10 more
TL;DR: The Polish population has a diverse mutation spectrum influenced by strong founder effects, however, families with strong breast/ovarian cancer history who are negative for these common mutations should be offered a complete BRCA gene screening, including MLPA analysis.
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Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs.
Jesús Villar,Jesús Villar,Nuria E. Cabrera,Francisco Valladares,Francisco Valladares,Milena Casula,Carlos Flores,Lluís Blanch,María Elisa Quílez,Norberto Santana-Rodríguez,Robert M. Kacmarek,Arthur S. Slutsky,Arthur S. Slutsky,Arthur S. Slutsky +13 more
TL;DR: The findings demonstrate that the Wnt/β-catenin signaling pathway is modulated very early by MV in lungs without preexistent lung disease, suggesting that activation of this pathway could play an important role in both VILI and lung repair.