M
Maria Colombino
Researcher at National Research Council
Publications - 60
Citations - 1525
Maria Colombino is an academic researcher from National Research Council. The author has contributed to research in topics: Melanoma & CDKN2A. The author has an hindex of 19, co-authored 60 publications receiving 1314 citations. Previous affiliations of Maria Colombino include University of Sassari & University of Genoa.
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Journal ArticleDOI
BRAF/NRAS Mutation Frequencies Among Primary Tumors and Metastases in Patients With Melanoma
Maria Colombino,Mariaelena Capone,Amelia Lissia,Antonio Cossu,Corrado Rubino,Vincenzo De Giorgi,Daniela Massi,Ester Fonsatti,Stefania Staibano,Oscar Nappi,Elena Pagani,Milena Casula,Antonella Manca,MariaCristina Sini,Renato Franco,Gerardo Botti,Corrado Caracò,Nicola Mozzillo,Paolo A. Ascierto,Giuseppe Palmieri +19 more
TL;DR: The findings about the prevalence of BRAF/NRAS/p16CDKN2A mutations in paired tumor lesions from patients with melanoma may be useful in the management of this disease.
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Multiple Molecular Pathways in Melanomagenesis: Characterization of Therapeutic Targets
Giuseppe Palmieri,MariaNeve Ombra,Maria Colombino,Milena Casula,MariaCristina Sini,Antonella Manca,Panagiotis Paliogiannis,Paolo A. Ascierto,Antonio Cossu +8 more
TL;DR: The known molecular mechanisms underlying either intrinsic and acquired drug resistance either alternative roads to melanoma pathogenesis, which may become targets for innovative anticancer approaches are summarized.
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BRAF and PIK3CA genes are somatically mutated in hepatocellular carcinoma among patients from South Italy.
Maria Colombino,Pasquale Sperlongano,Francesco Izzo,Fabiana Tatangelo,Gerardo Botti,Angela Lombardi,Marina Accardo,Luciano Tarantino,I. Sordelli,Massimo Agresti,Alberto Abbruzzese,Michele Caraglia,Giuseppe Palmieri +12 more
TL;DR: It is indicated that mutational activation of both BRAF and PIK3CA genes does contribute to hepatocellular tumorigenesis at somatic level in Southern Italian population.
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COX-2 expression positively correlates with PD-L1 expression in human melanoma cells
Gerardo Botti,Federica Fratangelo,Margherita Cerrone,Giuseppina Liguori,Monica Cantile,Anna Maria Anniciello,Stefania Scala,Crescenzo D'Alterio,Chiara Trimarco,Angela Ianaro,Giuseppe Cirino,Corrado Caracò,Maria Colombino,Giuseppe Palmieri,Stefano Pepe,Paolo A. Ascierto,Francesco Sabbatino,Giosuè Scognamiglio +17 more
TL;DR: COX-2 expression correlates with and modulates PD-L1 expression in melanoma cells and helps to prevent melanoma progression and immune evasion as well as to enhance the anti-tumor activity of PD-1/PD-L 1 based immunotherapy for the treatment of melanoma patients with or without BRAF/NRAS mutations.
Journal ArticleDOI
BRAF Gene Is Somatically Mutated but Does Not Make a Major Contribution to Malignant Melanoma Susceptibility: The Italian Melanoma Intergroup Study
Milena Casula,Maria Colombino,Maria P. Satta,Antonio Cossu,Paolo A. Ascierto,Giovanna Bianchi-Scarrà,Daniele Castiglia,Mario Budroni,Carla Rozzo,Antonella Manca,Amelia Lissia,Annangela Carboni,Elisabetta Petretto,Sabrina M.R. Satriano,Gerardo Botti,Michela Mantelli,Paola Ghiorzo,Michael R. Stratton,Fraficesco Tanda,Giuseppe Palmieri +19 more
TL;DR: Analysis of either blood DNA from a large collection of MM patients or matched MM tissues from a subset of such patients revealed that BRAF is somatically mutated and does not play a major role in melanoma susceptibility.