Min Li

TL;DR: A novel mechanism of TBI-associated coagulopathy in mice is defined, early predictive markers are identified, andAlternative therapeutic targets are provided to provide alternative therapeutic targets.

TL;DR: A novel procoagulant activity of CL and CL-exposed mitochondria that may contribute to traumatic brain injury-associated coagulopathy is uncovered and potential pathways to block this activity are identified.

TL;DR: A novel synergistic action between VWF and cellular microvesicles in TBI-induced vascular leakage and coagulopathy is uncovered and protective effects of rADAMTS-13 are demonstrated.

TL;DR: It is shown in mouse models that the apoptotic cell-scavenging factor lactadherin, given at a single dose of 400 μg/kg 30 minutes before (preconditioning) or 30 minutes after cerebral fluid percussion injury, prevented coagulopathy as defined by clotting time, fibrinolysis, intravascular fibrin deposition, and microvascular bleeding of the lungs.

TL;DR: The results demonstrate a causal role of pcEV in preeclampsia and identify microvesicle clearance as a new therapeutic strategy for the treatment of this pregnancy-associated complication.