Min Pi

TL;DR: Data suggest that 1,25(OH)(2)D(3) is an important regulator of FGF23 production by osteoblasts in bone and may be to act as a counterregulatory phosphaturic hormone to maintain phosphate homeostasis in response to vitamin D.

TL;DR: Reverse transcription-PCR analyses showed that mouse GPRC6A is widely expressed in mouse tissues, including bone, calvaria, and the osteoblastic cell line MC3T3-E1, and suggest that in addition to sensing amino acids, G PRC 6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor and a candidate for mediating extracellular calcium-sensed responses in osteoblasts and possibly other

TL;DR: The overall function of GPRC6A may be to coordinate the anabolic responses of multiple tissues through the sensing of extracellular amino acids, osteocalcin and divalent cations.

TL;DR: It is found that GPRC6A is a candidate for mediating the response to Ocn in the bone‐pancreas endocrine loop regulating insulin signaling, and intraperitoneal injection of Ocn stimulated ERK activity in the pancreas and increased serum insulin levels in wild‐type mice, but these responses were markedly attenuated in Gprc6a−/− mice.

TL;DR: Using size-fractionated subsets of cDNA from the first finger stage, two sets of gridded libraries were constructed for cDNA sequencing and the ESTs represent approximately 40% of genes expressed in late development, assuming that the non-redundant ESTs correspond to independent genes.