GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome
Min Pi,Ling Chen,Min-Zhao Huang,Wenyu Zhu,Brian Ringhofer,Junming Luo,Lane K. Christenson,Benyi Li,Jianghong Zhang,P. David Jackson,Pieter W. Faber,Kurt R. Brunden,John J. Harrington,L. Darryl Quarles +13 more
TLDR
The overall function of GPRC6A may be to coordinate the anabolic responses of multiple tissues through the sensing of extracellular amino acids, osteocalcin and divalent cations.Abstract:
Background
GPRC6A is a widely expressed orphan G-protein coupled receptor that senses extracellular amino acids, osteocalcin and divalent cations in vitro. The physiological functions of GPRC6A are unknown.read more
Citations
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Endocrine regulation of male fertility by the skeleton
Franck Oury,Grzegorz Sumara,Olga Sumara,Mathieu Ferron,Haixin Chang,Charles E. Smith,Louis Hermo,Susan S. Suarez,Bryan L. Roth,Patricia Ducy,Gerard Karsenty +10 more
TL;DR: It is shown that, in males, bone acts as a regulator of fertility, and the physiological repertoire of osteocalcin is expanded, providing the first evidence that the skeleton is an endocrine regulator of reproduction.
Journal ArticleDOI
New insights into the biology of osteocalcin
TL;DR: It is suggested that the ability of osteocalcin to function both locally in bone and as a hormone depends on a novel post-translational mechanism that alters osteoccin's affinity for the bone matrix and bioavailability.
Journal ArticleDOI
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population
Ryo Takata,Shusuke Akamatsu,Michiaki Kubo,Atsushi Takahashi,Naoya Hosono,Takahisa Kawaguchi,Tatsuhiko Tsunoda,Johji Inazawa,Naoyuki Kamatani,Osamu Ogawa,Tomoaki Fujioka,Yusuke Nakamura,Hidewaki Nakagawa +12 more
TL;DR: Five new loci for prostate cancer susceptibility are reported here, at 5p15 (λ-corrected probability PGC = 3.9 × 10−18), GPRC6A/RFX6 (PGC = 1.6 ×10−12), 13q22 ( PGC = 2.8 × 10–10−9), C2orf43 (PGD = 7.5 × 10.–8) and FOXP4 (PGE = 7−8).
Journal ArticleDOI
Paracrine and endocrine actions of bone—the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts
TL;DR: The recent progresses in the paracrine and endocrine functions of the secretory proteins of osteoblasts, osteocytes, and osteoclasts are reviewed, revealing connections of the skeleton with other tissues and providing added insights into the pathogenesis of degenerative diseases affecting multiple organs and the drug discovery process.
Journal ArticleDOI
Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis.
Zuzana Saidak,Pierre J. Marie +1 more
TL;DR: This review focuses on the more recent knowledge of strontium signaling in bone cells and describes how the resulting pharmacological actions on bone metabolism have important therapeutic implications in the treatment of age-related bone loss and possibly other disorders.
References
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Journal ArticleDOI
Endocrine Regulation of Energy Metabolism by the Skeleton
Na Kyung Lee,Hideaki Sowa,Eiichi Hinoi,Mathieu Ferron,Jong Deok Ahn,Cyrille Confavreux,Romain Dacquin,Patrick J. Mee,Marc D. McKee,Dae Young Jung,Zhiyou Zhang,Jason K. Kim,Franck Mauvais-Jarvis,Patricia Ducy,Gerard Karsenty +14 more
TL;DR: It is shown that mice lacking the protein tyrosine phosphatase OST-PTP are hypoglycemic and are protected from obesity and glucose intolerance because of an increase in beta-cell proliferation, insulin secretion, and insulin sensitivity, and in vivo osteocalcin can improve glucose tolerance.
Journal ArticleDOI
Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice
TL;DR: It is shown that long-term treatment of WT mice with osteocalcin can significantly weaken the deleterious effect on body mass and glucose metabolism of gold thioglucose-induced hyperphagia and high-fat diet and suggest that osteocalin may be of value in the treatment of metabolic diseases.
Journal ArticleDOI
A PCR primer bank for quantitative gene expression analysis
Xiaowei Wang,Brian Seed +1 more
TL;DR: An experimentally validated algorithm for the identification of transcript-specific PCR primers on a genomic scale that can be applied to real-time PCR with sequence-independent detection methods is presented.
Journal ArticleDOI
Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues
Shuyuan Yeh,Meng Yin Tsai,Meng Yin Tsai,Qingquan Xu,Xiao Min Mu,Henry A. Lardy,Ko En Huang,Hank Lin,Shauh Der Yeh,Saleh Altuwaijri,Xinchang Zhou,Lianping Xing,Brendan F. Boyce,Mien Chie Hung,Su Zhang,Lin Gan,Chawnshang Chang +16 more
TL;DR: The cre-lox ARKO mouse provides a much-needed in vivo animal model to study androgen functions in the selective androgen target tissues in female or male mice, suggesting potential defects in female fertility and/or ovulation.
Journal ArticleDOI
Osteoclast-derived activity in the coupling of bone formation to resorption
T. John Martin,Natalie A. Sims +1 more
TL;DR: It is argued that osteoclasts contribute in important ways to the transiently activated osteoclast, and stimulate osteoblast lineage cells to begin replacing the resorbed bone in each BMU.