H
Hideaki Mizuno
Researcher at Chugai Pharmaceutical Co.
Publications - 21
Citations - 2774
Hideaki Mizuno is an academic researcher from Chugai Pharmaceutical Co.. The author has contributed to research in topics: Cancer & Gene expression. The author has an hindex of 10, co-authored 21 publications receiving 2252 citations. Previous affiliations of Hideaki Mizuno include Institute for Advanced Study & Kyushu Institute of Technology.
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Journal ArticleDOI
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
William A. Freed-Pastor,Hideaki Mizuno,Xi Zhao,Anita Langerød,Sung Hwan Moon,Ruth Rodriguez-Barrueco,Anthony M. Barsotti,Agustin Chicas,Wencheng Li,Alla Polotskaia,Mina J. Bissell,Timothy F. Osborne,Bin Tian,Scott W. Lowe,Jose M. Silva,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Arnold J. Levine,Jill Bargonetti,Carol Prives +19 more
TL;DR: It is found that mutant p53 depletion is sufficient to phenotypically revert breast cancer cells to a more acinar-like morphology, which implicate the mevalonate pathway as a therapeutic target for tumors bearing mutations in p53.
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PrognoScan: a new database for meta-analysis of the prognostic value of genes
TL;DR: PrognoScan employs the minimum P-value approach for grouping patients for survival analysis that finds the optimal cutpoint in continuous gene expression measurement without prior biological knowledge or assumption and, as a result, enables systematic meta-analysis of multiple datasets.
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Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas.
Hirokazu Okayama,Takashi Kohno,Yuko Ishii,Yoko Shimada,Kouya Shiraishi,Reika Iwakawa,Koh Furuta,Koji Tsuta,Tatsuhiro Shibata,Seiichiro Yamamoto,Shun-ichi Watanabe,Hiromi Sakamoto,Kensuke Kumamoto,Seiichi Takenoshita,Noriko Gotoh,Hideaki Mizuno,Akinori Sarai,Shuichi Kawano,Rui Yamaguchi,Satoru Miyano,Jun Yokota +20 more
TL;DR: An extensive genome-wide expression profiling of 226 primary human stage I-II lung adenocarcinomas helps identify patients who may gain the most benefit from adjuvant chemotherapy after surgical resection and further stratify more or less aggressive subgroups of triple-negative lung ADC.
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Molecular classification of prostate cancer using curated expression signatures
TL;DR: A microarray dataset characterizing 281 prostate cancers from a Swedish watchful-waiting cohort provided useful unique molecular profiles for prostate cancer prognosis, helping to predict poor outcome in patients with low or average Gleason scores.
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The Dictyostelium Developmental cDNA Project: Generation and Analysis of Expressed Sequence Tags from the First-Finger Stage of Development
Takahiro Morio,Hideko Urushihara,Tamao Saito,Yoshihiro Ugawa,Hideaki Mizuno,Motonobu Yoshida,Ryuji Yoshino,Biswa Nath Mitra,Min Pi,Tomihiro Sato,Keiko Takemoto,Hiroo Yasukawa,Jeffrey G. Williams,Mineko Maeda,Ikuo Takeuchi,Hiroshi Ochiai,Yoshimasa Tanaka +16 more
TL;DR: Using size-fractionated subsets of cDNA from the first finger stage, two sets of gridded libraries were constructed for cDNA sequencing and the ESTs represent approximately 40% of genes expressed in late development, assuming that the non-redundant ESTs correspond to independent genes.