Identification of a Novel Extracellular Cation-sensing G-protein-coupled Receptor
Min Pi,Pieter W. Faber,George Mbella Ekema,P. David Jackson,Anthony E. Ting,Nancy M. Wang,Michelle Fontilla-Poole,Robert W. Mays,Kurt R. Brunden,John J. Harrington,L. Darryl Quarles +10 more
TLDR
Reverse transcription-PCR analyses showed that mouse GPRC6A is widely expressed in mouse tissues, including bone, calvaria, and the osteoblastic cell line MC3T3-E1, and suggest that in addition to sensing amino acids, G PRC 6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor and a candidate for mediating extracellular calcium-sensed responses in osteoblasts and possibly otherAbout:
This article is published in Journal of Biological Chemistry.The article was published on 2005-12-02 and is currently open access. It has received 290 citations till now. The article focuses on the topics: GPRC6A & Extracellular.read more
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Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
TL;DR: In vitro assays performed on primary murine bone cells confirmed the dual action of strontium ranelate in vivo as an anabolic agent on bone remodeling, which stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization.
Calcimimetics with potent and selective activity on the parathyroid calcium receptor (cytoplasmic Ca21yhyperparathyroidismyparathyroid cellsyNPS R-568yNPS R-467)
Edward F. Nemeth,Michael E. Steffey,L Ance G. Hammerland,C. P. Hung,Bradford C. Van Wagenen,E Ric G. Delmar,Manuel F. Balandrin +6 more
TL;DR: In this paper, phenylalkylamine com-pounds, typified by NPS R-568 and its deschloro derivative NPSR-467, increased the concentration of cytoplasmic Ca 2 1 ([Ca 2 1 ] i ) in bovine parathyroid cells and inhibited PTH secretion at nanomolar concentrations.
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Endocrine regulation of male fertility by the skeleton
Franck Oury,Grzegorz Sumara,Olga Sumara,Mathieu Ferron,Haixin Chang,Charles E. Smith,Louis Hermo,Susan S. Suarez,Bryan L. Roth,Patricia Ducy,Gerard Karsenty +10 more
TL;DR: It is shown that, in males, bone acts as a regulator of fertility, and the physiological repertoire of osteocalcin is expanded, providing the first evidence that the skeleton is an endocrine regulator of reproduction.
Journal ArticleDOI
The contribution of bone to whole-organism physiology
Gerard Karsenty,Mathieu Ferron +1 more
TL;DR: The skeleton is an example of how a whole-organism approach to physiology can broaden the functions of a given organ, reveal connections of this organ with others such as the brain, pancreas and gut, and shed new light on the pathogenesis of degenerative diseases affecting multiple organs.
Journal ArticleDOI
New insights into the biology of osteocalcin
TL;DR: It is suggested that the ability of osteocalcin to function both locally in bone and as a hormone depends on a novel post-translational mechanism that alters osteoccin's affinity for the bone matrix and bioavailability.
References
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Cloning and characterization of an extracellular Ca 2+ -sensing receptor from bovine parathyroid
Edward M. Brown,Gerardo Gamba,Daniela Riccardi,Michael Lombardi,Robert Butters,Olga Kifor,Adam Sun,Adam Sun,Matthias A. Hediger,Jonathan Lytton,Steven C. Hebert +10 more
TL;DR: The cloning of complementary DNA encoding an extracellular Ca2+ -sensing receptor from bovine parathyroid is reported with pharmacological and functional properties nearly identical to those of the native receptor.
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Charles S. Zuker,Nicholas J. P. Ryba,Gregory A. Nelson,Mark A. Hoon,Jayaram Chandrashekar,Yifeng Zhang +5 more
TL;DR: A detailed analysis of the patterns of expression of T1Rs and T2Rs is presented, thus providing a view of the representation of sweet and bitter taste at the periphery.
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Omar A. Coso,Mario Chiariello,Jin-Chen Yu,Hidemi Teramoto,Piero Crespo,Ningzhi Xu,Toru Miki,J. Silvio Gutkind +7 more
TL;DR: It is shown that in COS-7 cells, activated Ras effectively stimulates MAPK but poorly induces JNK activity, which strongly support a critical role for Rac1 and Cdc42 in controlling the JNK signaling pathway.
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Greg Nelson,Jayaram Chandrashekar,Mark A. Hoon,Luxin Feng,Grace Zhao,Nicholas J. P. Ryba,Charles S. Zuker +6 more
TL;DR: This work identifies and characterize a mammalian amino-acid taste receptor and shows that sequence differences in T1R receptors within and between species (human and mouse) can significantly influence the selectivity and specificity of taste responses.