G
Giorgos C. Karakousis
Researcher at University of Pennsylvania
Publications - 354
Citations - 12569
Giorgos C. Karakousis is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Melanoma. The author has an hindex of 40, co-authored 275 publications receiving 8474 citations. Previous affiliations of Giorgos C. Karakousis include Yale University & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Exosomal PD-L1 Contributes to Immunosuppression and is Associated with anti-PD-1 Response
Chen Gang,Alexander C. Huang,Wei Zhang,Wei Zhang,Gao Zhang,Wu Min,Wei Xu,Zi-Li Yu,Jiegang Yang,Jiegang Yang,Beike Wang,Beike Wang,Honghong Sun,Hou-Fu Xia,Qiwen Man,Wenqun Zhong,Wenqun Zhong,Leonardo F. Antelo,Bin Wu,Xuepeng Xiong,Xiaoming Liu,Lei Guan,Lei Guan,Ting Li,Ting Li,Shujing Liu,Ruifeng Yang,Youtao Lu,Liyun Dong,Suzanne McGettigan,Rajasekharan Somasundaram,Ravi Radhakrishnan,Gordon B. Mills,Yiling Lu,Junhyong Kim,Youhai H. Chen,Haidong Dong,Yi-Fang Zhao,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Meenhard Herlyn,E. John Wherry,Xiaowei Xu,Wei Guo +44 more
TL;DR: It is reported that metastatic melanomas release extracellular vesicles, mostly in the form of exosomes, that carry PD-L1 on their surface, suggesting a mechanism by which tumours could evade the immunesystem, and the potential application ofExosomal PD- L1 to monitor patient responses to checkpoint therapies.
Journal ArticleDOI
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
Alexander C. Huang,Michael A. Postow,Michael A. Postow,Robert J. Orlowski,Rosemarie Mick,Bertram Bengsch,Sasikanth Manne,Wei Xu,Shannon Harmon,Josephine R. Giles,Brandon Wenz,Matthew Adamow,Deborah Kuk,Katherine S. Panageas,Cristina Carrera,Cristina Carrera,Phillip Wong,Felix Quagliarello,Bradley Wubbenhorst,Kurt D'Andrea,Kristen E. Pauken,Ramin S. Herati,Ryan P. Staupe,Jason M. Schenkel,Suzanne McGettigan,Shawn Kothari,Sangeeth M. George,Robert H. Vonderheide,Ravi K. Amaravadi,Giorgos C. Karakousis,Lynn M. Schuchter,Xiaowei Xu,Katherine L. Nathanson,Jedd D. Wolchok,Tara C. Gangadhar,E. John Wherry +35 more
TL;DR: Blood profiling of peripheral blood from patients with stage IV melanoma before and after treatment with the PD-1-targeting antibody pembrolizumab is used to identify pharmacodynamic changes in circulating exhausted-phenotype CD8 T cells (Tex cells) and identify a clinically accessible potential on-treatment predictor of response to PD- 1 blockade.
Journal ArticleDOI
TOX transcriptionally and epigenetically programs CD8 + T cell exhaustion
Omar Khan,Josephine R. Giles,Sierra McDonald,Sasikanth Manne,Shin Foong Ngiow,Kunal P. Patel,Michael T. Werner,Alexander C. Huang,Katherine A. Alexander,Jennifer E. Wu,John Attanasio,Patrick Yan,Sangeeth M. George,Bertram Bengsch,Bertram Bengsch,Ryan P. Staupe,Greg Donahue,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Jonathan Kaye,Shelley L. Berger,E. John Wherry +25 more
TL;DR: The transcription factor TOX is a central regulator of the transcriptional and epigenetic development of exhausted T cells in mice, and robust expression of TOX results in commitment to Tex cells by translating persistent stimulation into a distinct Tex cell transcriptionaland epigenetic developmental program.
Journal ArticleDOI
A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
Alexander C. Huang,Robert J. Orlowski,Robert J. Orlowski,Xiaowei Xu,Rosemarie Mick,Sangeeth M. George,Sangeeth M. George,Patrick Yan,Sasikanth Manne,Adam A. Kraya,Bradley Wubbenhorst,Liza Dorfman,Kurt D'Andrea,Brandon Wenz,Shujing Liu,Lakshmi Chilukuri,Andrew Kozlov,Mary Carberry,Lydia Giles,Melanie W. Kier,Felix Quagliarello,Suzanne McGettigan,Kristin Kreider,Lakshmanan Annamalai,Qing Zhao,Robin Mogg,Wei Xu,Wendy M. Blumenschein,Jennifer H. Yearley,Gerald P. Linette,Ravi K. Amaravadi,Lynn M. Schuchter,Ramin S. Herati,Bertram Bengsch,Bertram Bengsch,Katherine L. Nathanson,Michael D. Farwell,Giorgos C. Karakousis,E. John Wherry,Tara C. Mitchell +39 more
TL;DR: A rapid and potent anti-tumor response was identified, with 8 of 27 patients experiencing a complete or major pathological response after a single dose of anti-PD-1, all of whom remain disease free.
Journal ArticleDOI
Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
Jean-Christophe Beltra,Sasikanth Manne,Mohamed S. Abdel-Hakeem,Makoto Kurachi,Josephine R. Giles,Zeyu Chen,Valentina Casella,Shin Foong Ngiow,Omar Khan,Yinghui Jane Huang,Patrick Yan,Kito Nzingha,Wei Xu,Ravi K. Amaravadi,Xiaowei Xu,Giorgos C. Karakousis,Tara C. Mitchell,Lynn M. Schuchter,Alexander C. Huang,E. John Wherry +19 more
TL;DR: A four-cell-stage developmental framework for Tex cells is defined and the control mechanisms underlying subset transitions are identified and a key interplay between TCF1, T-bet, and Tox is defined in the process.