Ming Liu

TL;DR: The immunogenicity of ccRCC tumors cannot be explained by mutation load or neo-antigen load, but is highly correlated with MHC class I antigen presenting machinery expression (APM), and both APM and T cell levels are negatively associated with subclone number.

TL;DR: It is shown that the serine esterase is a membrane-associated, disulphide-linked dimer that has trypsin-like properties but is not a general protease, and in density gradient centrifugation it sediments with perforin, and it is secreted by Tc cells during their cytolytic attack on target cells, and antiserum to Tc-cell serine Esterase reacts with the enzyme in Th/c cells.

TL;DR: It is demonstrated that key angiogenic and immune profiles of the tumor microenvironment may affect TKI response and have the potential to inform treatment personalization in patients with RCC.

TL;DR: Targeted TGF-β signalling blockade in helper T cells elicits an effective tissue-level cancer defence response that can provide a basis for therapies directed towards the cancer environment.

TL;DR: In this article, paired single-cell RNA (scRNA) and T-cell receptor (TCR) sequencing of 167,283 cells from multiple tumor regions, lymph node, normal kidney, and peripheral blood of two immune checkpoint blockade (ICB)-naive and four ICB-treated patients to map the ccRCC immune landscape.