S
Shile Zhang
Researcher at Illumina
Publications - 60
Citations - 7278
Shile Zhang is an academic researcher from Illumina. The author has contributed to research in topics: Computer science & Medicine. The author has an hindex of 19, co-authored 41 publications receiving 6196 citations. Previous affiliations of Shile Zhang include University of Washington & Institute for Systems Biology.
Papers
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Journal ArticleDOI
The MicroRNA Spectrum in 12 Body Fluids
Jessica A. Weber,David Baxter,Shile Zhang,David Huang,Kuo-How Huang,Ming-Jen Lee,David J. Galas,David J. Galas,Kai Wang +8 more
TL;DR: The changes in miRNA spectra observed in the urine samples from patients with different urothelial conditions demonstrates the potential for using concentrations of specific miRNAs in body fluids as biomarkers for detecting and monitoring various physiopathological conditions.
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Circulating microRNAs, potential biomarkers for drug-induced liver injury
Kai Wang,Shile Zhang,Bruz Marzolf,Pamela Troisch,Amy Brightman,Zhiyuan Hu,Leroy Hood,David J. Galas +7 more
TL;DR: It is demonstrated that specific microRNA species, such as mir-122 and mir-192, both are enriched in the liver tissue and exhibit dose- and exposure duration-dependent changes in the plasma that parallel serum aminotransferase levels and the histopathology of liver degeneration, but their changes can be detected significantly earlier.
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Export of microRNAs and microRNA-protective protein by mammalian cells
TL;DR: The results point to a hitherto unrecognized and uncharacterized miRNA trafficking system in mammalian cells that is consistent with the cell–cell communication hypothesis.
Journal ArticleDOI
Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors
Jack F. Shern,Li Chen,Juliann Chmielecki,Jun S. Wei,Rajesh Patidar,Mara Rosenberg,Lauren Ambrogio,Daniel Auclair,Jianjun Wang,Young K. Song,Catherine Tolman,Laura Hurd,Hongling Liao,Shile Zhang,Dominik Bogen,Andrew S. Brohl,Sivasish Sindiri,Daniel Catchpoole,Thomas C. Badgett,Gad Getz,Jaume Mora,James R. Anderson,Stephen X. Skapek,Frederic G. Barr,Matthew Meyerson,Matthew Meyerson,Douglas S. Hawkins,Javed Khan +27 more
TL;DR: This is the most comprehensive genomic analysis of rhabdomyosarcoma to date, finding multiple genes were recurrently altered, including NRAS, KRAS, HRAS, FGFR4, PIK3CA, CTNNB1, FBXW7, and BCOR.
Journal ArticleDOI
Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations
Thomas F. Eleveld,Derek A. Oldridge,Virginie Bernard,Jan Koster,Leo Colmet Daage,Sharon J. Diskin,Linda Schild,Nadia Bessoltane Bentahar,Angela Bellini,Mathieu Chicard,Eve Lapouble,Valérie Combaret,Patricia Legoix-Né,Jean Michon,Trevor J. Pugh,Lori S. Hart,JulieAnn Rader,Edward F. Attiyeh,Jun S. Wei,Shile Zhang,Arlene Naranjo,Julie M. Gastier-Foster,Michael D. Hogarty,Shahab Asgharzadeh,Malcolm A. Smith,Jaime M. Guidry Auvil,Thomas B.K. Watkins,Danny A. Zwijnenburg,Marli E. Ebus,Peter van Sluis,Anne Hakkert,Esther M. van Wezel,C. Ellen van der Schoot,Ellen M. Westerhout,Johannes H. Schulte,Godelieve A.M. Tytgat,M. Emmy M. Dolman,Isabelle Janoueix-Lerosey,Daniela S Gerhard,Huib N. Caron,Olivier Delattre,Javed Khan,Rogier Versteeg,Gudrun Schleiermacher,Jan J. Molenaar,John M. Maris +45 more
TL;DR: It is shown that RAS-MAPK pathway mutations may function as a biomarker for new therapeutic approaches to refractory disease and provide a rationale for genetic characterization of relapse neuroblastomas.