Raakhee Vijayaraghavan

TL;DR: A scalable approach to sequence and quantify RNA molecules in isolated neuronal nuclei from a postmortem brain, generating 3227 sets of single-neuron data from six distinct regions of the cerebral cortex demonstrates a robust and scalable method for identifying and categorizing single nuclear transcriptomes.

TL;DR: In this article, paired single-cell RNA (scRNA) and T-cell receptor (TCR) sequencing of 167,283 cells from multiple tumor regions, lymph node, normal kidney, and peripheral blood of two immune checkpoint blockade (ICB)-naive and four ICB-treated patients to map the ccRCC immune landscape.

TL;DR: Comprehensive targeted methylation sequencing of 9223 CpG sites in plasma cfDNA from patients with common advanced cancers detects the presence of cancer and underlying cancer type with high accuracy and corresponds with treatment outcomes.

TL;DR: In this article, the median expression of human endogenous retroviruses (hERVs) was used as a potential biomarker for prognosis, relapse, and resistance to chemotherapy in stage II and III colorectal cancer.

TL;DR: In this paper , the interplay between genetic and microenvironment intra-tumor heterogeneity across different tumor consensus molecular subtypes (CMS) and primary tumor location was analyzed. And the authors provided an exhaustive portrait of cancer-related genes with predictive value of CRC progression and metastasis development.