Showing papers in "Cancer Cell in 2021"

TL;DR: Tumor mutational burden reflects cancer mutation quantity, and higher TMB results in more neo-antigens, increasing chances for T cell recognition, and clinically correlates with better ICI outcomes, Nevertheless, TMB is an imperfect response biomarker.

TL;DR: In this article, a visual tool integrating transcriptomic and genomic data provides a global tumor portrait, describing the tumor framework, mutational load, immune composition, anti-tumor immunity, and immunosuppressive escape mechanisms.

TL;DR: In this paper, the authors used tumor expression data and non-negative matrix factorization to identify four SCLC subtypes defined largely by differential expression of transcription factors ASCL1, NEUROD1, and POU2F3 or low expression of all three transcription factor signatures accompanied by an Inflamed gene signature.

TL;DR: In this paper, a validated antibody assay against SARS-CoV-2 spike protein was used to determine a high seroconversion rate (94%) in 200 patients with cancer in New York City that had received full dosing with one of the FDA-approved COVID-19 vaccines.

TL;DR: This article identified key phosphorylation events (e.g., phosphorylated PTPN11 and PLCG1) as potential switches mediating oncogenic pathway activation, as well as potential targets for EGFR-, TP53-, and RB1-altered tumors.

TL;DR: In this paper, the authors used a dual-recombinase genetic mouse model of spontaneous PDAC to delete Col1 specifically in myofibroblasts, which results in significant reduction of total stromal Col1 content and accelerates the emergence of PanINs and PDAC, decreasing overall survival.

TL;DR: In this paper, the authors assessed the seroconversion rates and anti-SARS-CoV-2 spike protein antibody titers following the first and second dose of BNT162b2 and mRNA-1273 vaccines in patients with cancer in US and Europe from January to April 2021.

TL;DR: In this article, single-cell RNA-and ATAC-sequencing was used to examine the immune cell dynamics in 22 patients with advanced triple-negative breast cancer (TNBC) treated with paclitaxel or its combination with the anti-PD-L1 atezolizumab.

TL;DR: Zhang et al. as mentioned in this paper showed that tumor-secreted protease cathepsin C (CTSC) promotes breast-to-lung metastasis by regulating recruitment of neutrophils and formation of extracellular traps (NETs).

TL;DR: In this paper, the mesenchymal subtype of glioblastoma is determined by both cancer cell-intrinsic alterations and extrinsic cellular interactions, but remains poorly understood.

TL;DR: In this article, single-cell transcriptomes of cancer and immune cells from metastatic renal cell carcinoma (RCC) patients before or after immune checkpoint blockade (ICB) exposure are characterized.

TL;DR: Cell-extrinsic contributions to the metabolic activities of immune cells are discussed and future directions to better understand how immune cells meet their metabolic demands in the TME are proposed, which can be leveraged for therapeutic benefit.

TL;DR: In this paper, the authors performed single-cell RNA and T-cell receptor sequencing on 164,722 individual cells from tumor and adjacent non-tumor tissue in patients with clear cell renal cell carcinoma (ccRCC) across disease stages: early, locally advanced, and advanced/metastatic.

TL;DR: In this article, the potential of inhibiting different cell-cycle proteins for cancer therapy was discussed, including CDK4/6 inhibitors, with the clinical success of CDK-6 inhibitors.

TL;DR: In this paper, a proteogenomic study of 108 human papilloma virus (HPV)-negative head and neck squamous cell carcinomas (HNSCCs) is presented.

TL;DR: The human microbiome constitutes a complex multikingdom community that symbiotically interacts with the host across multiple body sites and has been suggested to influence the development, progression, metastasis formation, and treatment response of multiple cancer types as mentioned in this paper.

TL;DR: Cancer-associated fibroblasts (CAF) are a poorly characterized cell population in the context of liver cancer, and as discussed by the authors investigates CAF functions in intrahepatic cholangiocarcinoma (ICC), a highly desmoplastic liver tumor.

TL;DR: In this paper, the authors adapted the KrasLSL-G12D/+;p53f/f autochthonous model of lung adenocarcinoma to express the CAR target ROR1.

TL;DR: Using tumor models defective in the MMR gene Mlh1, it is shown that dMLH1 tumor cells accumulate cytosolic DNA and produce IFN-β in a cGAS-STING-dependent manner, which renders d MLH1 tumors slowly progressive and highly sensitive to checkpoint blockade.

TL;DR: The main immunomodulatory effects of targeted anticancer agents are discussed and potential avenues to harness them in support of superior clinical efficacy are explored.

TL;DR: In this article, the authors summarize key features of biomolecular condensates, note where they have been implicated-or will likely be implicated-in oncogenesis, describe evidence that the pharmacodynamics of cancer therapeutics can be greatly influenced by condensate, and discuss some of the questions that must be addressed to further advance and treatment of cancer.

TL;DR: In this article, the authors show that the premetastatic niche in the liver is induced by bacteria dissemination from primary colorectal cancer (CRC) patients, and that increased levels of PV-1, a marker of impaired Gut vascular barrier (GVB), is associated with liver bacteria dissemination and metachronous distant metastases.

TL;DR: In this article, the heterogeneity of small cell lung cancer (SCLC) is defined by differential expression of ASCL1, NEUROD1, and POU2F3.

TL;DR: In this paper, the stromal composition of 18 murine tissues and 5 spontaneous tumor models was analyzed using mass cytometry, with an emphasis on mesenchymal phenotypes.

TL;DR: Restoring TBK1 signaling is sufficient to bypass mtp53 and lead to restored immune cell function and cancer cell eradication and therapeutic approaches that restoreTBK1 function could potentially reactivate immune surveillance and eliminate mTP53 tumors.

TL;DR: In this article, paired single-cell RNA (scRNA) and T-cell receptor (TCR) sequencing of 167,283 cells from multiple tumor regions, lymph node, normal kidney, and peripheral blood of two immune checkpoint blockade (ICB)-naive and four ICB-treated patients to map the ccRCC immune landscape.

TL;DR: In this article, the authors provided a high-resolution dissection of the entire tumor ecosystem through single-cell RNA-sequencing analysis of 15 ovarian tumors, and revealed chemokine receptor-ligand interactions within and across compartments as potential mechanisms mediating immune cell infiltration.