Mingquan Zheng

TL;DR: Although both cytokines regulated CXC chemokines and granulocyte colony–stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury, and data support the concept that the TH17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites.

TL;DR: Independent requirements for IL-12 and IL-23 in pulmonary host defense against K. pneumoniae are demonstrated, the former of which is required for IFN-γ expression and the latter of which has been required forIL-17 production.

TL;DR: It is shown in vivo that intact Toll-like receptor 4 signaling in the lung is required for induction of both the p19 transcript of IL-23 and IL-17 protein elaboration in response to Klebsiella pneumoniae, and a direct role for IL- 23 is suggested in CD8+ T cell IL- 17 production.

TL;DR: It is demonstrated that IL‐17R signaling plays a critical role in the development of TNBS‐induced colitis and may represent a target for therapeutic intervention for IBD.

TL;DR: Chronic‐binge ethanol feeding may be a useful model to study the early stages of alcoholic liver injury and IL‐22 treatment could be a potential therapeutic option to ameliorate alcoholic liver disease, due to its antioxidant, antiapoptotic, antisteatotic, proliferative, and antimicrobial effects with the added benefit of potentially few side effects.